Hexamethyldisilazane was reacted with formamides to generate ,-disubstituent formimidamide, after which a reaction with sulfonamides was induced to form sulfonylformamidines. This protocol can be applied for arylformamidine formation in which anilines are used as substrates under optimized conditions. The advantages of this method are high efficiency, structural diversity in products with good yields, and applicability in large-scale operations.
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Hexamethyldisilazane-Mediated Amidination of Sulfonamides and Amines with Formamides.
J Org Chem
November 2022
Department of Chemistry, National Chung Hsing University, Taichung 402, Taiwan.
Hexamethyldisilazane was reacted with formamides to generate ,-disubstituent formimidamide, after which a reaction with sulfonamides was induced to form sulfonylformamidines. This protocol can be applied for arylformamidine formation in which anilines are used as substrates under optimized conditions. The advantages of this method are high efficiency, structural diversity in products with good yields, and applicability in large-scale operations.
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