Objective: To compare short-term and long-term outcomes after transcanal endoscope-assisted with microscope-assisted ossiculoplasty using the Fisch titanium total prosthesis (FTTP).
Study Design: Retrospective chart review.
Setting: Tertiary referral center.
Patients: Pediatric (<18 yr of age) and adult patients undergoing ossiculoplasty with the FTTP between January 2016 and December 2019.
Intervention: Transcanal endoscope-assisted (n = 30) or microscope-assisted (n = 76) ossiculoplasty with the FTTP. In the microscopic group, 48 were performed through the ear canal and 28 by retroauricular approach.
Main Outcome Measure: Short-term (3 mo) and long-term (average 20.2 mo) PTA 0.5-2kHz air and bone conduction thresholds were evaluated.
Results: In total, 106 patients were included. Nine of 30 (30.0%) of endoscopic and 15 of 76 (19.7%) of microscopic patients were pediatric. Endoscopic preoperative air conduction PTA 0.5-2kHz was 52.1 ± 15.8 dB and 52.2 ± 17.9 dB for the microscopic group ( p > 0.05). Three months postoperative endoscopic air conduction PTA 0.5-2kHz was 37.6 ± 17.4 dB (14.5 dB improvement) and 44.6 ± 19.9 dB (7.6 dB improvement) in the microscopic group ( p > 0.05). Three months postoperative endoscopic PTA 0.5-2kHz ABG was 26.8 ± 16.6 dB and 28.4 ± 14.7 dB in the microscopic group ( p > 0.05). Latest follow-up endoscopic air conduction PTA 0.5-2kHz audiogram (mean follow-up, 20.6 ± 10.4 mo) was 36.1 ± 18.2 dB (16.0 dB improvement) and 40.1 ± 16.8 dB (12.1 dB improvement) in the microscopic group (mean follow-up, 19.9 ± 10.3 mo)( p > 0.05). For endoscopic air conduction PTA 0.5-2kHz , between the 3 months and latest follow-up audiogram, 25.0% showed improvement, 50.0% remained stable, and 25.0% deteriorated. In the microscopic group, 26.7% improved, 46.6% remained stable, and 26.7% deteriorated ( p > 0.05).
Conclusion: Our study shows that hearing results with the Fisch titanium total prosthesis are in line with literature. Endoscope-assisted total ossiculoplasty proves to be a suitable technique with comparable results to the microscopic approach.
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http://dx.doi.org/10.1097/MAO.0000000000003733 | DOI Listing |
Clin Microbiol Infect
December 2024
Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium. Electronic address:
Objectives: Temocillin is a β-lactam antibiotic used for preventing or treating bacterial infections in liver-transplanted children. We characterized its pharmacokinetics in plasma and ascitic fluid and proposed dosing regimens that maximize achievement of effective drug exposures in this patient group.
Methods: Patients aged 6-36 months received 25 mg/kg/12h (n=14) or 25 mg/kg/8h (n=23).
Am J Ophthalmol
December 2024
Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China; School of Medicine, Nankai University, Tianjin, China; Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Affiliated Ophthalmology Hospital, Tianjin, China; Nankai Eye Institute, Nankai University, Tianjin, China. Electronic address:
Purpose: To analyze the effect of individual parameters on the postoperative refractive outcomes of small incision lenticule extraction in myopic eyes using machine learning methods.
Design: Retrospective Clinical Cohort Study METHODS: We included 477 patients (922 eyes) of small incision lenticule extraction at Tianjin Ophthalmology Hospital and divided the patients into two groups to analyzed the factors affecting postoperative refractive outcomes based on the label of postoperative spherical equivalent (SE) ≤ -0.50D.
Clin Genitourin Cancer
December 2024
Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, FL. Electronic address:
Objective: To assess the association of being overweight or obese with Nonmuscle invasive bladder cancer (NMIBC) recurrence, stage progression, and grade progression.
Methods: Patients with NMIBC were included and categorized into 3 groups based on their body mass index (BMI): normal weight, overweight, and obese. Recurrence was defined as any histologically proven bladder cancer on subsequent transurethral resection of bladder tumor (TURBT).
Am J Otolaryngol
December 2024
Department of Otorhinolaryngology & Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; School of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Otorhinolaryngology & Head and Neck Surgery, New Taipei Municipal TuCheng Hospital, New Taipei City, Taiwan.
Background: Sudden sensorineural hearing loss is an acute hearing disorder typically managed using steroids. However, prognostic factors of diabetes mellitus (DM) patients undergoing intra-tympanic steroid injections (ITSIs) are unclear. We explored the prognostic factors for ITSI in DM patients with unilateral SSNHL.
View Article and Find Full Text PDFInorg Chem
December 2024
Textile Pollution Controlling Engineering Center of Ministry of Ecology and Environment, College of Environmental Science and Engineering, Donghua University, Shanghai 201620, China.
Carbon capture and storage (CCS) from dilute sources is an important strategy for stabilizing the concentration of atmospheric carbon dioxide and global temperature. However, the adsorption process is extremely challenging due to the sluggish diffusion rate of dilute CO. Herein, -phthalic acid (PTA)-derived hierarchical porous activated carbon (PTA-C) with abundant micro- and mesopores was successfully prepared for dilute CO (2 vol %) capture at ambient conditions.
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