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Two-Center Validation of a Novel Quality Improvement Protocol to Avoid Postileostomy Morbidity Using Home Intravenous Fluids and Structured Daily Calls.
Dis Colon Rectum
April 2025
Department of Surgery, University of Florida College of Medicine, Gainesville, Florida.
Background: New ileostomates have higher rates of dehydration and readmission compared to patients undergoing other colorectal procedures.
Objective: We aimed to show the efficacy of a novel ileostomy-specific quality improvement protocol at an academic center with subsequent validation at another academic center.
Design: Prospective cohort study.
Smoking and Elevated Preneoadjuvant Chemoradiotherapy Serum Carcinoembryonic Antigen Levels Are Associated With High Tumor Regression Grade and Poor Survival in Patients With Locally Advanced Rectal Cancer.
Kaohsiung J Med Sci
March 2025
Department of Surgery, Chiayi Hospital, Ministry of Health and Welfare, Chiayi City, Taiwan.
Neoadjuvant chemoradiotherapy (NACRT) is the standard treatment for patients with locally advanced rectal cancer (LARC). Tumor regression grade (TRG) is an essential prognostic factor in determining treatment efficacy. However, the potential factors influencing TRG in patients with rectal cancer who have received NACRT have not been investigated.
View Article and Find Full Text PDFBoth direct and indirect suppression of MCL1 synergizes with BCLXL inhibition in preclinical models of gastric cancer.
Cell Death Dis
March 2025
National Center of Technology Innovation for Animal Model, National Human Diseases Animal Model Resource Center, NHC Key Laboratory of Human Disease Comparative Medicine, The Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Despite the progress of treatment in gastric cancer (GC), the overall outcomes remain poor in patients with advanced diseases, underscoring the urgency to develop more effective treatment strategies. BH3-mimetic drugs, which inhibit the pro-survival BCL2 family proteins, have demonstrated great therapeutic potential in cancer therapy. Although previous studies have implicated a role of targeting the cell survival pathway in GC, the contribution of different pro-survival BCL2 family proteins in promoting survival and mediating resistance to current standard therapies in GC remains unclear.
View Article and Find Full Text PDFBackground: Survival rates after a diagnosis of cancer are improving. Poorly managed gastrointestinal (GI) side effects can interfere with delivery of curative cancer treatment. Long-term physical side effects of cancer therapy impinge on quality of life in up to 25% of those treated for cancer, and GI side effects are the most common and troublesome.
View Article and Find Full Text PDFIntroduction: Screening for colorectal cancer decreases mortality. Fecal occult blood testing (FOBT) decreases some barriers to screening, however positive results require colonoscopy. We evaluated factors associated with colonoscopy completion for community health center (CHC) patients after positive FOBT.
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