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| http://dx.doi.org/10.1503/cmaj.220260 | DOI Listing |
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Acquired Nail Hypertrophy Due to Nickel Contact Allergy with Dermoscopic findings: A Case Report and Literature Review.
Clin Cosmet Investig Dermatol
December 2024
Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Nickel stands as one of the prevalent contact allergens, but acquired nail hypertrophy presenting as ACD due to nickel exposure is infrequent. Here we report a case of acquired nail hypertrophy stemming from ACD due to nickel, displaying an uneven coloration, along with nail grooves, deck distortion damage, small surface pits and ecchymosis beneath the damaged deck. The patient limited nickel contact and recovered after 11 months of follow-up.
View Article and Find Full Text PDFMetal Ion Release from Orthodontic Archwires: A Comparative Study of Biocompatibility and Corrosion Resistance.
Molecules
November 2024
BT Orthodontic Office "Galeria Uśmiechów", Polskie Towarzystwo Techniki Ortodontycznej, Plac Piłsudskiego 25, 51-152 Wroclaw, Poland.
This study investigates the release of metal ions from commonly used orthodontic archwires, specifically, stainless steel (SS), nickel-titanium (NiTi), chromium-cobalt (CrCo), and titanium-molybdenum (TMA) alloys. To simulate oral conditions, each type of wire was immersed in artificial saliva at body temperature for a four-week period. Ion release levels were analyzed through ICP-OES mass spectrometry.
View Article and Find Full Text PDFInterference of the positioning of nickel, chromium and cobalt in the results of patch tests.
An Bras Dermatol
December 2024
Department of Medicine, Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, SP, Brazil.
Background: The positioning of substances, which are co-sensitizers and/or with a tendency to cross-react, is not considered in the technique when applying patch tests (PT).
Objective: To investigate the interference of the positioning of nickel (Ni), chromium (Cr) and cobalt (Co) in patch tests (PT) results, when applied close or distant from each other.
Methods: PT were performed in patients suspected of allergic contact dermatitis (ACD), using the standard battery (SB), with substances showing a tendency towards cross-react and co-sensitizers applied far apart, and an additional battery (AB) with the metals placed close to each other.
Differential Diagnosis of Irritant Versus Allergic Contact Dermatitis Based on Noninvasive Methods.
Dermatol Pract Concept
October 2024
Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
Introduction: Irritant contact dermatitis (ICD) is characterized by direct injury to the epidermal cells, activating the innate immune response. Allergic contact dermatitis (ACD), in contrast, is delineated by a delayed hypersensitivity reaction of type IV. Despite the distinct etiopathogenic mechanisms under-pinning each condition, the differentiation between them presents a significant diagnostic challenge.
View Article and Find Full Text PDFAssessment of dermal sensitization by nickel salts in a novel humanized TLR-4 mouse model.
J Immunotoxicol
December 2024
Allergy and Clinical Immunology Branch (ACIB), National Institute of Occupational Safety and Health (NIOSH), Morgantown, WV, USA.
Article Synopsis
- - The study aimed to evaluate a new mouse model with a humanized Toll-like receptor-4 (hTLR-4) to investigate nickel allergy by assessing how it affects skin sensitization in mice.
- - Mice with the hTLR-4 receptor were exposed to nickel sulfate and showed significantly higher immune responses, including increased lymph node cellularity and elevated levels of IgE and various cytokines compared to hTLR-4-negative mice.
- - Results indicate that the hTLR-4 mouse model is more susceptible to nickel sensitization, making it a promising tool for future research on nickel allergy and its mechanisms.
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