AI Article Synopsis
- The rhizome tuber known as 'Bai Fuzi' in China has been used in traditional medicine for treating neurological diseases, especially Parkinson's disease (PD).
- Researchers isolated nineteen compounds from Bai Fuzi, among which four (berberine, nicotinamide, rutin, and 5-caffeoylquinic acid) were reported for the first time.
- Six of these compounds showed moderate inhibition of the MAO-B enzyme, and two exhibited significant protective effects in a PD cell model, indicating Bai Fuzi's potential as an anti-PD herb in traditional Chinese medicine.
Article Abstract
The rhizome tuber of is known as 'Bai Fuzi' in China and has been ethnomedicinally used to treat various neurological diseases. It is considered to possess anti-Parkinson's disease (PD) potential, but the active compounds responsible for that is still unclear. In this work, nineteen compounds were isolated and identified from rhizome tuber of this plant, among which four were firstly reported, i.e. berberine (), nicotinamide ), rutin () and 5-caffeoylquinic acid (). Six compounds (, , , , and ) exhibited moderate inhibitory activity against MAO-B with IC of 118.8, 45.6, 96.2, 65.8, 40.0, and 49.8 M, and two compounds ( and ) displayed significant protective effect on 6-OHDA-induced PC-12 cell model. The molecular docking of the bioactive compounds and MAO-B was carried out to explore the binding mode. The findings revealed the potential of as anti-PD herb and its inclusion in TCM could be explored.
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| http://dx.doi.org/10.1080/14786419.2022.2137502 | DOI Listing |
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