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Notch3 deletion regulates HIV-1 gene expression and systemic inflammation to ameliorate chronic kidney disease.
bioRxiv
June 2024
Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS.
Antiretroviral therapy (ART) has decreased HIV-1 associated morbidity. However, despite ART, immune cells remain latently infected and slowly release viral proteins, leading to chronic inflammation and HIV-1 associated comorbidities. New strategies are needed to target viral proteins and inflammation.
View Article and Find Full Text PDFNEF-Induced HIV-Associated Nephropathy Through HCK/LYN Tyrosine Kinases.
Am J Pathol
June 2023
Department of Microbiology/Immunology, University of Montreal, Montreal, Quebec, Canada; Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada. Electronic address:
HIV-1-associated nephropathy (HIVAN) is a severe complication of HIV-1 infection. To gain insight into the pathogenesis of kidney disease in the setting of HIV, a transgenic (Tg) mouse model [CD4C/HIV-negative regulator factor (Nef)] was used in which HIV-1 nef expression is under control of regulatory sequences (CD4C) of the human CD4 gene, thus allowing expression in target cells of the virus. These Tg mice develop a collapsing focal segmental glomerulosclerosis associated with microcystic dilatation, similar to human HIVAN.
View Article and Find Full Text PDFHIV-1 Proteins gp120 and Tat Promote Epithelial-Mesenchymal Transition and Invasiveness of HPV-Positive and HPV-Negative Neoplastic Genital and Oral Epithelial Cells.
Microbiol Spectr
December 2022
Department of Medicine, University of California-San Francisco, San Francisco, California, USA.
The incidence of human papillomavirus (HPV)-associated anogenital and oropharyngeal cancer in human immunodeficiency virus (HIV)-infected individuals is substantially higher than in HIV-uninfected individuals. HIV may also be a risk factor for the development of HPV-negative head and neck, liver, lung, and kidney cancer. However, the molecular mechanisms underlying HIV-1-associated increase of epithelial malignancies are not fully understood.
View Article and Find Full Text PDFHIV-1-Associated Kidney Disease in an Elite Controller.
AIDS Patient Care STDS
November 2022
Université Paris Cité, Faculté de Médecine, Paris, France.
GWAS in Mice Maps Susceptibility to HIV-Associated Nephropathy to the Locus.
J Am Soc Nephrol
January 2022
Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York.
Background: To gain insight into the pathogenesis of collapsing glomerulopathy, a rare form of FSGS that often arises in the setting of viral infections, we performed a genome-wide association study (GWAS) among inbred mouse strains using a murine model of HIV-1 associated nephropathy (HIVAN).
Methods: We first generated F1 hybrids between HIV-1 transgenic mice on the FVB/NJ background and 20 inbred laboratory strains. Analysis of histology, BUN, and urinary NGAL demonstrated marked phenotypic variation among the transgenic F1 hybrids, providing strong evidence for host genetic factors in the predisposition to nephropathy.
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