AI Article Synopsis

  • Chronic pancreatitis (CP) can present as either painful or painless, with a notable percentage (26.9%) of patients experiencing painless CP.
  • Painless CP patients are generally older at the time of diagnosis (61.7 years) compared to those with painful CP (52.5 years) and have a lower occurrence of alcoholic causes.
  • Both groups show similar rates of diabetes and pancreatic exocrine insufficiency, highlighting the need for regular monitoring of all CP patients, regardless of pain status.

Article Abstract

Introduction: Although abdominal pain is the most prevalent and disabling symptom in patients with chronic pancreatitis (CP), there are also patients who have painless CP.

Patients And Methods: We performed a retrospective analysis of patients with a diagnosis of CP. A total of 279 patients with definite CP with completed demographic and clinical data were included in the final analysis.

Results: There were 75 (26.9%) patients with painless CP. These patients had a significantly higher mean age at diagnosis, 61.7 years, than the 52.5 years of patients with pain ( < 0.001). Painless and painful CP had similar rates of diabetes mellitus (DM) (28.4% vs. 31.6%) and pancreatic exocrine insufficiency (PEI) (50.0% vs. 52.3%). Painless CP had lower rates of alcoholic etiology, 36.0%, than the 52.5% in painful CP ( < 0.05). Patients older than 55 at the time of CP diagnosis were associated with painless CP with an adjusted odds ratio (aOR) of 3.27 [95% confidence interval (CI): 1.62-6.60]. Alcoholic etiologies were not associated with painless CP, aOR of 0.51 (95% CI: 0.25-0.91).

Conclusion: Patients with painless CP had a significantly higher mean age than patients with painful CP and increased aOR for those older than 55 at CP diagnosis. Painless and painful CP patients had similar rates of DM and PEI, confirming the necessity of routine follow up in all patients with CP.

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Source
http://dx.doi.org/10.1080/00365521.2022.2137692DOI Listing

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