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Mechanisms of resistance to cell wall and plasma membrane targeting antifungal drugs in Candida species isolated in Africa.
Expert Rev Anti Infect Ther
January 2025
Pathogenic Yeast Research Group, Department of Microbiology and Biochemistry, University of the Free State, Bloemfontein, South Africa.
Introduction: There is a rise in the emergence of multidrug resistant fungal pathogens worldwide, including in Africa.
Method: This systematic review summarized the published data on the mechanisms and epidemiology of antifungal resistance in species in Africa between 2000 and early 2024.
Result: Seventeen reports from seven African countries were analyzed but due to the paucity of data, the prevalence of antifungal resistant isolates in Africa could not be estimated.
Multiparametric LC-MS/MS method for simultaneous determination of eleven antifungal drugs and metabolites in human plasma.
J Pharm Biomed Anal
January 2025
Department of Pharmacology, Montpellier University Hospital, Avenue du Doyen Gaston Giraud, Montpellier 34090, France; Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), INSERM, University Montpellier, Montpellier 34090, France. Electronic address:
Article Synopsis
- A new liquid chromatography-tandem mass spectrometry method has been created to measure 11 antifungal drugs and their metabolites in human plasma, essential for monitoring treatment in immunocompromised patients with fungal infections.
- * This method not only optimizes settings and preparation techniques for accurate detection but also follows strict FDA and EMA guidelines to ensure reliability and performance.
- * With a quick processing time of 5 minutes per sample and minimal plasma requirement, this method supports better antifungal therapy management in critical care settings.
Isavuconazole Pharmacokinetics in Critically Ill Patients: Relationship with Clinical Effectiveness and Patient Safety.
Antibiotics (Basel)
July 2024
Intensive Care Unit, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain.
Isavuconazole is used to treat fungal infections. This study aims to describe isavuconazole pharmacokinetics in critically ill patients and evaluate their relationship with clinical efficacy and patient safety. We conducted a prospective, observational study in patients treated with intravenous isavuconazole.
View Article and Find Full Text PDFPharmacokinetics of isavuconazonium sulfate and its active metabolite isavuconazole in healthy dogs.
PLoS One
July 2024
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, United States of America.
Article Synopsis
- * Isavuconazole, a new antifungal, shows promise with an expanded antifungal activity and a potentially safer profile compared to traditional azoles, though its effects in dogs haven't been fully studied.
- * A study on healthy beagle dogs determined the pharmacokinetics of isavuconazole after different administration methods, revealing key data about peak plasma concentrations and half-life, while reporting one incident of anaphylaxis and no major adverse effects.
Case report: Disseminated mucormycosis misdiagnosed as malignancy developed from allergic bronchopulmonary mycosis caused by following SARS-CoV-2 infection in a woman.
Front Med (Lausanne)
June 2024
Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China.
Mucormycosis has become more prevalent during the COVID-19 pandemic and is associated with a high mortality rate. However, concurrent host allergic reactions, invasive pulmonary mucormycosis, and disseminated mucormycosis are rarely reported. Herein, we describe a case of disseminated mucormycosis initially misdiagnosed as a malignancy that developed from allergic bronchopulmonary mycosis caused by in a woman with post-SARS-CoV-2 infection.
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