AI Article Synopsis
- - The study identifies a specific factor that is dysregulated in various cancers and specifically contributes to the progression of hepatocellular carcinoma (HCC), highlighting its association with poor clinical outcomes.
- - Increased expression levels of this factor correlate with enhanced cell invasion and migration, potentially due to changes in epithelial-mesenchymal transition linked to TOP2A.
- - The use of verteporfin revealed that the Hippo pathway plays a role in tumor progression, while miR-22-5p acts as an inhibitor of this progression by targeting the dysregulated factor.
Article Abstract
() are dysregulated in various types of cancer. However, how () contributes to hepatocellular carcinoma (HCC) progression remains elusive. Cohort analysis revealed that the increased expression of was associated with poor clinical outcomes and was significantly upregulated in HCC tissues and cell lines. , expression level is related to cell invasion and migration, which may be due to the alteration of epithelial-mesenchymal transition by the TOP2A. Moreover, we used verteporfin (a Hippo inhibitor) to test how the Hippo pathway promotes the effect of on the HCC phenotype and found that induces tumor progression through the Hippo pathway. Finally, miR-22-5p inhibited tumor progression by sponging .
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592219 | PMC |
| http://dx.doi.org/10.1155/2022/4277254 | DOI Listing |
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