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The current status and future prospects of CRISPR-based detection of monkeypox virus: A review.
Anal Chim Acta
January 2025
Department of Quality Control Material R&D, Shanghai Center for Clinical Laboratory, Shanghai, PR China; Department of Molecular Biology, Shanghai Center for Clinical Laboratory, Shanghai, PR China; Department of Molecular Diagnostic Innovation Technology, Shanghai Academy of Experimental Medicine, Shanghai, PR China. Electronic address:
Background: The current pandemic of 2022 global mpox (formerly known as monkeypox), caused by infection with monkeypox virus (MPXV), has now reached over 120 countries. This constitutes a critical public health issue requiring effective disease management and surveillance. Rapid and reliable diagnosis is conducive to the control of infection, early intervention, and timely treatment.
View Article and Find Full Text PDFChronological versus immunological aging: Immune rejuvenation to arrest cognitive decline.
Neuron
January 2025
Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel. Electronic address:
The contemporary understanding that the immune response significantly supports higher brain functions has emphasized the notion that the brain's condition is linked in a complex manner to the state of the immune system. It is therefore not surprising that immunity is a key factor in shaping brain aging. In this perspective article, we propose amending the Latin phrase "mens sana in corpore sano" ("a healthy mind in a healthy body") to "a healthy mind in a healthy immune system.
View Article and Find Full Text PDFPost-exposure prophylaxis for the prevention of measles: A systematic review.
Vaccine
January 2025
Centre for Immunization Surveillance and Programs, Infectious Disease and Vaccine Program Branch, Public Health Agency of Canada, 130 Colonnade Rd S, Nepean, ON K1A0K9, Canada; Department of Pediatrics, Faculty of Medicine, McGill University. Electronic address:
Background: In susceptible individuals, post-exposure prophylaxis (PEP) is often recommended following exposure to measles, however the data that these recommendations are based on are limited. The objective of this systematic review was to evaluate the efficacy/effectiveness and safety of immunoglobulins (Ig) or measles-containing vaccine (MCV) for the prevention of measles.
Methods: Prospective studies evaluating the use of Ig or MCV as PEP in susceptible individuals exposed to measles were eligible for inclusion.
Recent advances in HPV biotechnology: Understanding host-virus interactions and cancer progression-a review.
Int J Surg
October 2024
Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, Ethiopia.
Cervical cancer ranks as the fourth most common cancer among women globally, posing a significant mortality risk. Persistent infection with high-risk human papillomavirus (HPV) is the primary instigator of cervical cancer development, often alongside co-infection with other viruses, precipitating various malignancies. This study aimed to explore recent biotechnological advances in understanding HPV infection dynamics, host interactions, and its role in oncogenesis.
View Article and Find Full Text PDFHow to Identify Pesticide Targets?
J Agric Food Chem
January 2025
State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, P. R. China.
Pesticides are essential in contemporary agriculture, as they improve crop yields and quality while safeguarding against pests. However, long-term heavy use of traditional pesticides has led to increased pest resistance, while these pesticides are often toxic and less selective, and may also have adverse effects on the environment and nontarget organisms. To solve this problem, it is important to find new targets for pesticide to develop more effective and environmentally friendly alternatives.
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