Wound healing is known to be a complicated and intricate process and commonly classified as chronic or acute. Patients with chronic wounds are of public health concern, and require more attention onto skin lesions, including atopic dermatitis. Despite being a natural process, healing can be impaired by existing chronic de diseases such as diabetes, for example. Recently, wound dressings based in nanotechnology systems have emerged as a viable option to improve the healing process. Current advances in nanotechnology-based systems to release growth factors and bioactive agents represent a great opportunity to develop new therapies for wound treatments. It is essential that healthcare professionals understand the key processes involved in the healing cascade, to maximize care with these patients and minimize the undesirable outcomes of non-healing wounds. Therefore, this review aims to summarize the healing process phases and provide a general overview of dressings based in nanotechnology using biomaterials for the release of active agents in wound site.
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http://dx.doi.org/10.3390/ph15101286 | DOI Listing |
3 Biotech
January 2025
Department of Biology, Faculty of Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran.
In this study, chitosan/curcumin (CS/Cur) and chitosan/papain (CS/Pa) nanoparticles were prepared and then characterized by Fourier transform infrared (FTIR), X-ray diffraction (XRD), and differential light scattering (DLS). Subsequently, release rate, porosity, swelling, degradability, anti-inflammatory, antioxidant, antibacterial, and cell viability tests were conducted to investigate and compare the healing potential of the nanoparticles for various types of wounds. The results of FTIR, XRD, and DLS indicated that the nanoparticles were manufactured correctly with a hydrodynamic diameter of 429 nm (CS/Cur) and 460 nm (CS/Pa), and zeta potential of 4.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China; Key Laboratory of Agro-Products Quality and Safety Control in Storage and Transport Process, Ministry of Agriculture and Rural Affairs, Chinese Academy of Agricultural Sciences, Beijing 100193, China; Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address:
The development of functional hydrogel dressings with robust mechanical properties has posed a significant challenge in expediting the healing process of MRSA-infected wounds. To address this, a composite hydrogel, comprising carboxylated soybean cellulose nanocrystals (CNCs), poly(N-isopropyl acrylamide) (PNIPAM), dimethyl diallyl ammonium chloride (PDADMAC), and kaolin (CN/P-K) was synthesized. CNCs served to stabilize the interpenetrating polymer networks of PNIPAM and PDADMAC through hydrogen bonding and electrostatic interactions, respectively, while the kaolin interlayer improved the material toughness.
View Article and Find Full Text PDFAsian Pac J Cancer Prev
December 2024
Department of Epidemiology and Biostatistics, Salah Azaiz Institute of Cancer, Tunis, Tunisia.
Background: Cancer is a major cause of morbidity and mortality in Tunisia. The objectives of our study were to estimate the incidence level of the main cancer sites in Northern Tunisia in 2023 and to dress projections till 2040.
Methods: The population based cancer registry database of northern Tunisia was the source of cases of this study.
Int J Biol Macromol
December 2024
Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.
Globally, traumatic injuries and severe hemorrhagic wounds resulting from natural disasters, wars, traffic accidents, and operation rooms, especially during birth, are among the most difficult humanitarian and economic problems. Thus, the priority in emergency medical treatment is reducing unexpected blood loss, which can significantly influence a patient's rescue and recovery speed. For the immediate cessation of bleeding in severe hemorrhagic wounds and to speed up their healing, environmentally friendly γ-ionizing irradiation technology was used to develop innovative natural-based hydrogels impregnated with traditional medicinal plant extracts (MPE) with proven hemostatic and bactericidal potential as potential dressings for hemostasis, infection control, and wound healing.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Materials and Metallurgical Engineering, Amirkabir University of Technology, Tehran, 15875-4413, Iran.
This study explores the impact of metallic shells by electroforming method on the mechanical behavior of thermoplastic polyurethane (TPU)-based lattice structures. First, the TPU lattice structures were printed by additive manufacturing technique. Then layers of Ni and Cu as a thin shell were dressed on the TPU lattice structures in the electroforming baths of Ni and Cu solutions.
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