Treatment of drug-resistant forms of cancer requires consideration of their hallmark features, such as abnormal cell death mechanisms or mutations in drug-responding molecular pathways. Malignant cells differ from their normal counterparts in numerous aspects, including copper metabolism. Intracellular copper levels are elevated in various cancer types, and this phenomenon could be employed for the development of novel oncotherapeutic approaches. Copper maintains the cell oxidation levels, regulates the protein activity and metabolism, and is involved in inflammation. Various copper-based compounds, such as nanoparticles or metal-based organic complexes, show specific activity against cancer cells according to preclinical studies. Herein, we summarize the major principles of copper metabolism in cancer cells and its potential in cancer theranostics.
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http://dx.doi.org/10.3390/molecules27207066 | DOI Listing |
Sci Rep
January 2025
College of Mathematics and Computer Science, Guangdong Ocean University, Zhanjiang, 524088, China.
To address the problems of complex cloud features in satellite cloud maps, inaccurate typhoon localization, and poor target detection accuracy, this paper proposes a new typhoon localization algorithm, named TGE-YOLO. It is based on the YOLOv8n model with excellent high-low feature fusion capability and innovatively achieves the organic combination of feature fusion, computational efficiency, and localization accuracy. Firstly, the TFAM_Concat module is creatively designed in the neck network, which comprehensively utilizes the detailed information of shallow features and the semantic information of deeper features, enhancing the fusion ability of features at each layer.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
Department of Chemistry, The University of Hong Kong, Hong Kong 999077, P. R. China.
Electron donor-acceptor complexes are commonly employed to facilitate photoinduced radical-mediated organic reactions. However, achieving these photochemical processes with catalytic amounts of donors or acceptors can be challenging, especially when aiming to reduce catalyst loadings. Herein, we have unveiled a framework-based heterogenization approach that significantly enhances the photoredox activity of perylene diimide species in radical addition reactions with alkyl silicates by promoting faster and more efficient electron donor-acceptor complex formation.
View Article and Find Full Text PDFMicrob Pathog
January 2025
High School of Technology Laayoune, Ibn Zohr University, Morocco.
Plant-microbe partnerships constitute a complex and intricately woven network of connections that have evolved over countless centuries, involving both cooperation and antagonism. In various contexts, plants and microorganisms engage in mutually beneficial partnerships that enhance crop health and maintain balance in ecosystems. However, these associations also render plants susceptible to a range of pathogens.
View Article and Find Full Text PDFBioelectrochemistry
January 2025
School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China; Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China. Electronic address:
A ratiometric electrochemical aptasensor was developed for ultra-sensitive detection of cortisol using aptamer (Apt) as recognition element, methylene blue (MB) as signal probe, and zirconium metal-organic framework (Zr-MOF) as carrier loaded with abundant MB for signal amplification. The carboxylated multi-walled carbon nanotubes (cMWCNTs)-modified Au electrode showed excellent electrochemical performance to immobilize complementary DNA (cDNA) for hybridizing with MB@Zr-MOF-Apt via amide bonds. In the presence of cortisol, it would compete with cDNA for binding the Apt, resulting in the detachment of MB@Zr-MOF-Apt complex from the electrode surface, and the electrochemical signal of MB was decreased, while that of [Fe(CN)] was basically unchanged.
View Article and Find Full Text PDFWater Res
January 2025
College of Environmental Science and Engineering, Yangzhou University, Yangzhou 225127, PR China; Key Laboratory of Arable Land Quality Monitoring and Evaluation, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou 225127, PR China; Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou 225127, Jiangsu, PR China; Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, PR China. Electronic address:
Endogenous nitrogen (N) release from lake sediments is one of main causes affecting water quality, which can be affected by the presence of iron (Fe) minerals and organic matter, especially low-molecular-weight organic acids (LMWOAs). Although these substances always coexist in sediments, their interaction effect on N fate is not yet clear. In this study, the role and mechanisms of the coexistence of iron mineral (ferrihydrite, Fh) and LMWOAs, i.
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