AI Article Synopsis
- A study analyzed data from 2000-2013 in Taiwan to explore the link between HPV infection and colorectal cancer (CRC), comparing 358 HPV-infected patients to 1432 HPV-uninfected patients.
- The findings showed that the HPV-infected group had a notably higher incidence of CRC, with an adjusted hazard ratio indicating a 63% increased risk of CRC associated with HPV.
- This research provides evidence suggesting a connection between HPV and CRC, highlighting the need for further investigation into HPV's role in the development of colorectal cancer.
Article Abstract
: Although human papillomavirus (HPV) is a major etiology of cervical and anogenital cancers, whether it is associated with colorectal carcinogenesis is yet undetermined. : The longitudinal association of HPV infection with colorectal cancer (CRC) was evaluated using 2000-2013 data from a nationwide Taiwanese claims database. In this retrospective cohort study, 358 patients with primary HPV diagnoses (HPV-infected cohort) and 1432 patients without such a diagnosis (HPV-uninfected cohort) were recruited between 2000 and 2006. Both cohorts were followed up to identify CRC incidences from 2006 to 2013. Hazard ratios (HRs) and their 95% confidence intervals (CIs) derived from Cox proportional hazards models were used to estimate the association between HPV and CRC risk. : The HPV-infected cohort had a significantly higher cumulative incidence of CRC than the HPV-uninfected cohort. The presence of HPV was associated with an increased risk of CRC (adjusted HR, 1.63; 95% CI, 1.02-3.62). Furthermore, the significant HPV-CRC risk association was evident in both sexes. : This population-based cohort study reveals longitudinal evidence that HPV is associated with an increased risk of CRC. Further studies are required to verify the role of HPV in colorectal carcinogenesis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610003 | PMC |
| http://dx.doi.org/10.3390/medicina58101461 | DOI Listing |
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