When designing scaffolds for bone tissue engineering (BTE), the wall shear stress (WSS), due to the fluid flow inside the scaffold, is an important factor to consider as it influences the cellular process involved in new tissue formation. The present work analyzed the average WSS in Schwartz diamond (SD) and gyroid (SG) scaffolds with different surface topologies and mesh elements using computational fluid dynamics (CFD) analysis. It was found that scaffold meshes with a smooth surface topology with tetrahedral elements had WSS levels 35% higher than the equivalent scaffold with a non-smooth surface topology with hexahedral elements. The present work also investigated the possibility of implementing the optimization algorithm simulated annealing to aid in the design of BTE scaffolds with a specific average WSS, with the outputs showing that the algorithm was able to reach WSS levels in the vicinity of 5 mPa (physiological range) within the established limit of 100 iterations. This proved the efficacy of combining CFD and optimization methods in the design of BTE scaffolds.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612273 | PMC |
| http://dx.doi.org/10.3390/ma15207375 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Numerical simulation study on the influence of bend diameter rate on the flow characteristics of nature gas hydrate particles.
Sci Rep
December 2024
Jiangsu Key Laboratory of Oil-Gas Storage and Transportation Technology, Changzhou University, Changzhou, 213164, Jiangsu, China.
Bend pipe is a common part of long distance pipeline. There is very important to study the flow law of hydrate particles in the bend pipe, and pipeline design will be optimized. In addition, the efficiency and safety of pipeline gas transmission will be improved.
View Article and Find Full Text PDFBouncing bubbles do not show water slip on smooth hydrophobic surfaces.
J Colloid Interface Sci
December 2024
Division of Physical Sciences and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
Hypothesis: The presence of hydrodynamic slip of water on smooth hydrophobic surfaces has been debated intensely over the last decades. In recent experiments, the stronger bounce of free-rising bubbles from smooth hydrophobic surfaces compared to smooth hydrophilic surfaces was interpreted as evidence for a significant water slip on smooth hydrophobic surfaces.
Experiments: To examine the possible water-slip effect, we conduct well-controlled experiments comparing the bouncing dynamics of millimeter-sized free-rising bubbles from smooth hydrophobic and hydrophilic surfaces.
Endograft-specific hemodynamics after endovascular aneurysm repair: a CFD analysis.
Sci Rep
December 2024
Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Intraluminal prosthetic graft thrombus (IPT) has been described in case of endovascular aortic pathology repair. This study aimed to assess hemodynamic indicators associated with various anatomical morphologies following endovascular aortic repair (EVAR), aiming to offer further references for the choice of clinical therapy. Six model models (normal, iliac compression, aortic compression, aortoiliac compression, iliac distortion, and long-leg stent) were established based on common anatomical morphologies following EVAR.
View Article and Find Full Text PDFHemodynamic comparisons of different shunt positions and geometrical model simplification strategies in the simulation of transjugular intrahepatic portosystemic shunt (TIPS).
Sci Rep
December 2024
School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, No. 516 Jungong Road, Yangpu District, Shanghai, 200093, China.
Transjugular intrahepatic portosystemic shunt (TIPS) is a widely used surgery for portal hypertensive patients, whose potential postoperative complications are closely related to the hemodynamic condition of the portal venous system. The selection of shunt position in the surgery may affect the postoperative hemodynamics; however, it is difficult for clinical studies to investigate the influence. Therefore, this study aims to employ the computational model simulating TIPS to compare the hemodynamic differences resulting from different shunt positions, and also to investigate the influences of different geometrical model simplification strategies used in the TIPS simulation.
View Article and Find Full Text PDFThe diagnostic value of two-dimensional ultrasound Su-RADS combined with shear wave elastography for benign and malignant lesions of the gastric wall.
BMC Med Imaging
December 2024
Department of Ultrasound, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China.
Objective: This study explored the value of stomach ultrasound reporting and data system (Su-RADS) and two-dimensional shear wave elastography (2D-SWE) in the diagnosis of benign and malignant lesions of the gastric wall, evaluating the feasibility of combining the two methods for the diagnosis of gastric wall lesions.
Methods: 113 patients with gastric wall lesions were examined after oral gastric ultrasound contrast agent, and the grades of the gastric wall lesions were classified according to Su-RADS. Moreover, 2D-SWE was performed to measure the E value of the lesions.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!