Transcription Factors in spp.: Classification, Regulation and a Newly Built Database.

Transcription factors (TFs) can regulate the synthesis of secondary metabolites through different metabolic pathways in spp. In this study, a set of 16 superfamilies, 45 PFAM families of TFs with the DNA-binding domains, seven zinc finger families and eight categories of the C2H2 TFs have been identified in spp. Among all the identified TFs, four superfamilies and six PFAM families are the fungal-specific types in this lineage. The Zn2Cys6 and fungal-specific domain regulators are found to be overwhelmingly predominated, while the C2H2 zinc finger class comprises a smaller regulator class. Since there are currently no databases that allow for easy exploration of the TFs in spp., based on over 50 references and 2405 homologous TFs, the first TFs pipeline-the Transcription Factor Database (ATFDB)-has been developed to accelerate the identification of metabolic regulation in various species. It would be useful to investigate the mechanisms behind the wide adaptability and metabolite diversity of spp.