This paper proposes an operating room (OR) scheduling model to assign a group of next-day patients to ORs while adhering to OR availability, priorities, and OR overtime constraints. Existing studies usually consider OR scheduling problems by ignoring the influence of uncertainties in surgery durations on the OR assignment. In this paper, we address this issue by formulating accurate patient waiting times as the cumulative sum of uncertain surgery durations from the robust discrete approach point of view. Specifically, by considering the patients' uncertain surgery duration, we formulate the robust OR scheduling model to minimize the sum of the fixed OR opening cost, the patient waiting penalty cost, and the OR overtime cost. Then, we adopt the box uncertainty set to specify the uncertain surgery duration, and a robustness coefficient is introduced to control the robustness of the model. This resulting robust model is essentially intractable in its original form because there are uncertain variables in both the objective function and constraint. To make this model solvable, we then transform it into a Mixed Integer Linear Programming (MILP) model by employing the robust discrete optimization theory and the strong dual theory. Moreover, to evaluate the reliability of the robust OR scheduling model under different robustness coefficients, we theoretically analyze the constraint violation probability associated with overtime constraints. Finally, an in-depth numerical analysis is conducted to verify the proposed model's effectiveness and to evaluate the robustness coefficient's impact on the model performance. Our analytical results indicate the following: (1) With the robustness coefficient, we obtain the tradeoff relationship between the total management cost and the constraint violation probability, i.e., a smaller robustness coefficient yields remarkably lower total management cost at the expense of a noticeably higher constraint violation probability and vice versa. (2) The obtained total management cost is sensitive to small robustness coefficient values, but it hardly changes as the robustness coefficient increases to a specific value. (3) The obtained total management cost becomes increasingly sensitive to the perturbation factor with the decrease in constraint violation probability.
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http://dx.doi.org/10.3390/ijerph192013685 | DOI Listing |
Repetitive TMS (rTMS) is a powerful neuroscientific tool with the potential to noninvasively identify brain-behavior relationships in humans. Early work suggested that certain rTMS protocols (e.g.
View Article and Find Full Text PDFBackground: Obesity, diabetes, hypertension, hyperlipidemia, and depression are relevant Alzheimer's Disease (AD) modifiable risk factors (RFs). However, little is known about how the duration of these conditions, influenced by unmodifiable AD risk factors, such as chromosomal sex and APOE genotype, affects the associated risk. Modeling interactions between patient's temporal and clinical patterns, integrated with the probability of developing AD remains challenging, particularly when considering the multifactorial progression of AD.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
December 2024
Department of Endocrinology, Bogomolets National Medical University, Kyiv, Ukraine.
Introduction: Post-COVID-19 syndrome (PCS) is a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-associated chronic condition characterized by long-term violations of physical and mental health. People with type 2 diabetes (T2D) are at high risk for severe COVID-19 and PCS.
Aim: The current study aimed to define the predictors of PCS development in people with T2D for further planning of preventive measures and improving patient outcomes.
J Hum Nutr Diet
February 2025
State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background: The association between tea consumption and mortality among very elderly individuals, with or without cardiovascular and cerebrovascular diseases (CCD), including stroke, remains unclear. This study hypothesised that a significant association exists.
Methods: We analysed data from two waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), spanning 1998/2000 to 2018, with a maximum follow-up of 20 years.
Phys Rev Lett
December 2024
University of Vienna, Faculty of Physics, Vienna Center for Quantum Science and Technology, Boltzmanngasse 5, 1090 Vienna, Austria.
From a quantum information perspective, verifying quantum coherence in a quantum experiment typically requires adjusting measurement settings or changing inputs. A paradigmatic example is that of a double-slit experiment, where observing the interference pattern on the screen in a series of experimental settings where one, the other, and both slits are open unambiguously proves quantum coherence. Here we show that this is not necessary by verifying quantum coherence in a network scenario without the need for inputs.
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