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T-2 toxin triggers lipid metabolism disorder and oxidative stress in liver of ducks.
Ecotoxicol Environ Saf
November 2024
College of Veterinary Medicine, China Agricultural University, Beijing 100193, China. Electronic address:
Article Synopsis
- - The study investigates the toxic effects of T-2 toxin on duck liver health, showing that high doses impair growth, feed intake, and liver function, while causing significant liver histological damage and elevated biochemical markers of liver injury.
- - Analysis revealed that T-2 exposure increased malondialdehyde levels and decreased antioxidant capacity, indicating oxidative stress and disrupted lipid metabolism in the ducks' livers.
- - Key genes involved in lipid metabolism and oxidative stress were significantly altered, suggesting that T-2 induces liver injury via these mechanisms in ducks, thus providing insights into potential detoxification strategies.
Peripheral serum iTRAQ-based proteomic characteristics of carbon tetrachloride-induced acute liver injury in .
Toxicol Rep
December 2024
National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, Beijing Key Laboratory for Safety Evaluation of Drugs, Beijing 100176, China.
Carbon tetrachloride (CCl) is a potent chemical compound that can induce liver cells necrosis. The purpose of this study was to evaluate the hepatic toxicity of CCl exposure in to explore the liver toxicity mechanism using a proteomic approach. One animal (no.
View Article and Find Full Text PDFUbiquitous occurrence of 1,4-dioxane in drinking water of China and its ecological and human health risk.
Sci Total Environ
April 2024
National Engineering Research Center of Industrial Wastewater Detoxication and Resource Recovery, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:
Article Synopsis
- A study analyzed 280 drinking water samples from 31 Chinese cities for 1,4-dioxane, finding its presence in roughly 80% of samples, with concentrations significantly higher in source water than in treated drinking water.
- Conventional water treatment methods were only somewhat effective in removing 1,4-dioxane, with higher efficiency seen in advanced treatment processes like ozonation.
- The primary sources of 1,4-dioxane were identified as municipal wastewater and industrial activities, raising concerns about its ecological and health risks, especially since its carcinogenic risk slightly exceeded U.S. EPA safety levels.
Solvent-like bis (2-chloro-1-methylethyl) ether occurrence in drinking water: Multidimensional risk assessment integrated health and aesthetic aspects.
J Hazard Mater
July 2023
Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; National Engineering Research Center of Industrial Wastewater Detoxication and Resource Recovery, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:
Bis (2-chloro-1-methylethyl) ether (DCIP), one U.S. Environmental Protection Agency priority pollutant, could pose health and/or odor risk in water environment.
View Article and Find Full Text PDFThe Effects of Drug Addiction and Detoxification on the Human Oral Microbiota.
Microbiol Spectr
February 2023
Shanxi Medical Universitygrid.263452.4, Taiyuan, People's Republic of China.
Drug addiction can powerfully and chronically damage human health. Detoxification contributes to health recovery of the body. It is well established that drug abuse is associated with poor oral health in terms of dental caries and periodontal diseases.
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