AI Article Synopsis
- Mammals, including humans, detect airborne chemicals using specialized proteins called G protein-coupled odorant receptors (ORs).
- The study focuses on a specific receptor, hOR1A1, using techniques like molecular modeling and mutations to understand how it recognizes various ligands.
- Results indicated that a part of the receptor known as the third extracellular loop (ECL3) plays a significant role in how effectively the receptor responds to certain odor molecules, affecting the receptor's potency and activation.
Article Abstract
Mammals recognize chemicals in the air via G protein-coupled odorant receptors (ORs). In addition to their orthosteric binding site, other segments of these receptors modulate ligand recognition. Focusing on human hOR1A1, which is considered prototypical of class II ORs, we used a combination of molecular modeling, site-directed mutagenesis, and in vitro functional assays. We showed that the third extracellular loop of ORs (ECL3) contributes to ligand recognition and receptor activation. Indeed, site-directed mutations in ECL3 showed differential effects on the potency and efficacy of both carvones, citronellol, and 2-nonanone.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604345 | PMC |
| http://dx.doi.org/10.3390/ijms232012501 | DOI Listing |
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