AI Article Synopsis
- Mammalian sirtuins (SIRT1-7) play crucial roles in various cellular functions, affecting processes like aging, apoptosis, and stress response.
- The review focuses on how these sirtuins influence cancer development in breast and prostate cancers, highlighting their roles in key mechanisms such as cell proliferation and metastasis.
- It also examines how sirtuins are regulated by microRNAs, emphasizing their impact on cancer progression in these specific types.
Article Abstract
Mammalian sirtuins (SIRT1-7) are involved in a myriad of cellular processes, including apoptosis, proliferation, differentiation, epithelial-mesenchymal transition, aging, DNA repair, senescence, viability, survival, and stress response. In this review, we discuss the current information on the mechanistic roles of SIRT1-7 and their downstream effects (tumor promotion or suppression) in cancers of the breast and prostate. Specifically, we highlight the involvement of sirtuins in the regulation of various proteins implicated in proliferation, apoptosis, autophagy, chemoresistance, invasion, migration, and metastasis of breast and prostate cancer. Additionally, we highlight the available information regarding SIRT1-7 regulation by miRNAs, laying much emphasis on the consequences in the progression of breast and prostate cancer.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600935 | PMC |
| http://dx.doi.org/10.3390/cancers14205118 | DOI Listing |
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