Recent Progress in Phage Therapy to Modulate Multidrug-Resistant , including in Human and Poultry.

is a multidrug-resistant and invasive pathogen associated with the etiopathology of both an increasing number of nosocomial infections and is of relevance to poultry production systems. Multidrug-resistant has been reported in connection to severe challenges to clinical treatment, mostly due to an increased rate of resistance to carbapenems. Amid the possible strategies aiming to reduce the insurgence of antimicrobial resistance, phage therapy has gained particular importance for the treatment of bacterial infections. This review summarizes the different phage-therapy approaches currently in use for multiple-drug resistant , including single phage therapy, phage cocktails, phage-antibiotic combination therapy, phage-derived enzymes active on and some novel technologies based on phage interventions. Although phage therapy represents a potential treatment solution for multidrug-resistant , further research is needed to unravel some unanswered questions, especially in regard to its in vivo applications, before possible routine clinical use.