AI Article Synopsis
- Researchers studied the inhalation delivery of ceftriaxone in mice using an ultrasonic nebulizer, focusing on particle sizes between 0.5-1.5 μm and mass concentrations of 0.01-0.6 μg/cm.
- They measured ceftriaxone levels in the blood and lungs over time using high-performance liquid chromatography, with doses ranging from 3-5 mg/kg.
- The treatment showed high antibacterial effectiveness, resulting in improved survival rates for mice infected with specific bacteria after receiving the ceftriaxone aerosol.
Article Abstract
Aerosol inhalation delivery of ceftriaxone in mice was investigated. An ultrasonic nebulizer within the ranges of mean particle diameter 0.5-1.5 μm and mass concentration 0.01-0.6 μg/cm was used in inhalation experiments. Pharmacokinetic measurements were carried out using a nose-only chamber. Ceftriaxone concentration in blood serum and its mass in the lungs of mice were measured as a function of time using high-performance liquid chromatography. The body-delivered dose was within the range 3-5 mg/kg. The antibacterial effect of aerosolized ceftriaxone was investigated for mice infected with 82 and ATCC 25 953. The survival rate for infected mice after the treatment with ceftriaxone aerosol revealed the high antibacterial efficiency of this kind of treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598611 | PMC |
| http://dx.doi.org/10.3390/antibiotics11101305 | DOI Listing |
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