Inflammatory, oxidative, and autoimmune responses cause severe damage to the nervous system inducing loss of myelin layers or demyelination. Even though demyelination is not considered a direct cause of skeletal muscle disease there is extensive damage in skeletal muscles following demyelination and impaired innervation. In vitro and in vivo evidence using exogenous antioxidants in models of demyelination is showing improvements in myelin formation alongside skeletal muscle recovery. For instance, exogenous antioxidants such as EGCG stimulate nerve structure maintenance, activation of glial cells, and reduction of oxidative stress. Consequently, this evidence is also showing structural and functional recovery of impaired skeletal muscles due to demyelination. Exogenous antioxidants mostly target inflammatory pathways and stimulate remyelinating mechanisms that seem to induce skeletal muscle regeneration. Therefore, the aim of this review is to describe recent evidence related to the molecular mechanisms in nerve and skeletal muscle regeneration induced by exogenous antioxidants. This will be relevant to identifying further targets to improve treatments of neuromuscular demyelinating diseases.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599955PMC
http://dx.doi.org/10.3390/biomedicines10102557DOI Listing

Publication Analysis

Top Keywords

exogenous antioxidants
20
skeletal muscle
20
muscle recovery
8
skeletal muscles
8
muscles demyelination
8
muscle regeneration
8
skeletal
7
exogenous
5
muscle
5
demyelination
5

Similar Publications

Background: Consumption of leafy vegetables is a primary route of cadmium (Cd) exposure in the human body. Salicylic acid (SA) is a major stress signaling molecule that alleviates Cd toxicity in various plants. Our study aimed to investigate the effects of different SA concentrations on spinach growth, cadmium accumulation, and stress resistance physiology under cadmium stress (50 µmol/L).

View Article and Find Full Text PDF

Adhesive and antibacterial guar gum-based nanocomposite hydrogel for remodeling wound healing microenvironment.

Int J Biol Macromol

December 2024

Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Engineering Research Centre of Chiral Hydroxyl Pharmaceutical, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China. Electronic address:

Hydrogels are promising wound dressings due to their extracellular matrix-like properties and tunable structure-function characteristics. Besides the physical isolation effect, hydrogel dressings are highly expected to possess tissue-adhesive performance and antibacterial capacity, which are beneficial for their clinical translations. Herein, a guar gum (GG)-based nanocomposite hydrogel was fabricated by mixing methacrylated GG (GGMA), acrylic acid, acrylated 3-aminophenylboronic acid, mangiferin (MF)-loaded cetyltrimethyl ammonium chloride (CTAC) micelles (MF@CTAC) and radical initiator.

View Article and Find Full Text PDF
Article Synopsis
  • - Copper pollution from industrial activities negatively affects plant growth and poses health risks through the food chain by accumulating in plants.! - DCPTA has been shown to help plants cope with copper stress by improving leaf pigment, photosynthesis, root growth, and antioxidant levels, while reducing copper accumulation in cucumber plants.! - Gene analysis indicates that specific genes related to copper metabolism, cell structure, and nitrogen processing are essential in regulating plant response to copper toxicity, suggesting that DCPTA can partially alleviate this stress in cucumbers.!
View Article and Find Full Text PDF

Functional interactions among H2O2, NO, H2S, and melatonin in the physiology, metabolism, and quality of horticultural Solanaceae.

J Exp Bot

December 2024

Group of Antioxidants, Free Radicals and Nitric Oxide in Biotechnology, Food and Agriculture, Department of Biochemistry, Cell and Molecular Biology of Plants, Estación Experimental del Zaidín, Spanish National Research Council (CSIC), Granada, Spain.

Cellular signaling is a key component of both intra- and intercellular communication, playing a crucial role in the development of higher plants as well as in their responses to environmental conditions of both abiotic and biotic origin. In recent decades, molecules such as hydrogen peroxide (H2O2), nitric oxide (NO), hydrogen sulfide (H2S), and melatonin have gained significant relevance in plant physiology and biochemistry due to their signaling functions and their interactions, forming a comprehensive cellular communication network. The Solanaceae family of plants includes a group of horticultural crops of great global importance, for instance, tomatoes, eggplants, and peppers, which are of major agroeconomic significance due to their widespread cultivation and consumption.

View Article and Find Full Text PDF

Melatonin (MT) serves an indispensable function in plant development and their response to abiotic stress. Although numerous drought-tolerance genes have been ascertained in wheat, further investigation into the molecular pathways controlling drought stress tolerance remains necessary. In this investigation, it was observed that MT treatment markedly enhanced drought resistance in wheat by diminishing malondialdehyde (MDA) levels and augmenting the activity of antioxidant enzymes POD, APX, and CAT compared to untreated control plants.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!