AI Article Synopsis
- Camrelizumab is a monoclonal antibody that blocks PD-1, helping the immune system fight certain cancers, including lung squamous cell carcinoma (LSCC).
- The most common side effect of camrelizumab is reactive cutaneous capillary endothelial proliferation (RCCEP), which occurred in a 76-year-old LSCC patient after treatment.
- After stopping camrelizumab, the RCCEP lesions healed, but reappeared after the patient underwent stereotactic body radiation therapy (SBRT), prompting further investigation into the relationship between SBRT and RCCEP.
Article Abstract
Camrelizumab (SHR-1210) is a humanized IgG4 monoclonal anti-programmed cell death protein 1 (PD-1) antibody that has been shown to inhibit the binding of PD-1 to PD-L1, thereby blocking the immune escape of various types of cancer, including lung squamous cell carcinoma (LSCC). Reactive cutaneous capillary endothelial proliferation (RCCEP) is the most common adverse event in camrelizumab-treated patients. Here, we introduce a case of LSCC with recall RCCEP induced by stereotactic body radiation therapy (SBRT). A 76-year-old LSCC patient developed RCCEP when he received camrelizumab and chemotherapy. After discontinuing camrelizumab treatment, the RCCEP lesions spontaneously regressed and fell off. However, when the patient received subsequent SBRT, the RCCEP occurred again at the same sites. This case may provide clues for additional study of the immune reactivation effect of SBRT or the underlying mechanism of RCCEP.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607856 | PMC |
| http://dx.doi.org/10.1186/s40164-022-00336-4 | DOI Listing |
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