Understanding the mechanisms of crustal deformation along convergent margins is critical to identifying seismogenic structures and assessing earthquake hazards for nearby urban centers. In the southern central Andes (28-33[Formula: see text]S), differences in the style of middle to upper-crustal deformation and associated seismicity are highlighted by the January 19th, 2021 (Mw 6.5) San Juan earthquake. We integrate waveforms recorded at regional and teleseismic distances with co-seismic displacements calculated from local Global Navigation Satellite System time series, to re-estimate the source parameters of the 2021 San Juan earthquake, confirming a mid-crustal nucleation depth (21 ± 2 km) and right-lateral transpressional mechanism. Considered alongside decades of seismic observations and geological data, this event provides evidence for retroarc deformation partitioning among inherited basement faults and upper-crustal structures in response to oblique convergence of the Nazca and South American plates. As they may transfer shortening to active upper-crustal faults associated with historically devastating shallower earthquakes, a better understanding of seismogenic basement faults such as the mid-crustal structure activated during the 2021 San Juan earthquake earthquake could help future re-assessment of the seismic risk in western Argentina.
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http://dx.doi.org/10.1038/s41598-022-22752-6 | DOI Listing |
ATS Sch
December 2024
Division of Pulmonary, Critical Care, Sleep Medicine & Physiology and.
Background: Subspecialty fellows are a unique group of trainees for whom there currently exist few opportunities to pursue formal training as clinician-educators, as singular fellowship programs often face significant obstacles to implementing such coursework.
Objective: To develop, implement, and assess a clinician-educator course for fellows from multiple subspecialty fellowships at a single large academic medical center.
Methods: Our course, entitled Fellow as Clinician-Educator, was initiated across numerous fellowship programs from August 2021 to April 2023 at University of California San Diego Health.
Addiction
January 2025
Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, USA.
Background And Aims: The opioid crisis continues to exert a tremendous toll in North America, with existing interventions often falling short of addressing ongoing needs. Psychedelics are emerging as a possible alternative therapy for mental health and substance use disorders. This study aimed to gather insights on how people use or are considering using psychedelics to manage opioid use disorder (OUD), how these experiences are perceived to impact opioid use and what these lessons imply for future research and practice.
View Article and Find Full Text PDFJAMA Oncol
January 2025
Department of Surgery, University of California, San Francisco.
Importance: Intratumoral immunotherapy that leverages the biological characteristics of high-risk ductal carcinoma in situ (DCIS) may be able to reduce the extent of surgical treatment and provide an alternative approach to improve patient outcomes.
Objective: To determine if combination intratumoral immunotherapy can activate immune cells to shrink or eliminate high-risk DCIS.
Design, Setting, And Participants: This phase 1 open-label nonrandomized clinical trial at a single academic center tested the safety and efficacy of intratumoral immunotherapy in patients with high-risk DCIS, defined as at least 2 of the following present: younger than 45 years, tumor size greater than 5 cm, high-grade, palpable mass, hormone receptor (HR)-negative, or ERBB2-positive.
JAMA Ophthalmol
January 2025
Division of Ophthalmology, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
Importance: A diverse ophthalmic workforce is key to equitable care, and identifying areas of underrepresentation is important in tackling vision care disparities.
Objective: To evaluate the diversity of applicants and matriculants in ophthalmology residency programs relative to medical school graduates and analyze the intersection of race and gender within this pathway.
Design, Setting, And Participants: This retrospective cross-sectional study conducted from 2022 to 2024 used representation quotients (RQs) using reports from the Association of University Professors of Ophthalmology and San Francisco Match, along with demographic data from the Association of American Medical Colleges from 2008 to 2021.
JAMA Netw Open
January 2025
Advancing New Standards in Reproductive Health, University of California, San Francisco, Oakland.
Importance: Since Dobbs v Jackson Women's Health Organization (Dobbs) removed federal abortion protections, people's views about alternative models of abortion care may have been impacted, yet research on this topic is limited.
Objective: To examine changes in national support for and personal interest in advance provision (AP) and over-the-counter (OTC) access to medication abortion.
Design, Setting, And Participants: Two nationally representative cross-sectional online surveys were administered to a market research firm's panel members who were assigned female at birth (AFAB) and aged 15 to 49 years from December 2021 to January 2022 (before Dobbs) and June to July 2023 (after Dobbs).
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