AI Article Synopsis

  • Current knowledge about infections after kidney transplantation, specifically Leishmaniasis, is very limited and lacks comprehensive guidelines for management.
  • A systematic review was conducted using various databases, covering all relevant English articles on Leishmaniasis in kidney transplant recipients, but findings could only be summarized descriptively due to study quality.
  • The review identified 70 studies with 159 case reports indicating mostly adult Caucasian male patients from endemic regions, showing delayed diagnosis and treatment, with mixed outcomes from available treatments leading to serious complications.

Article Abstract

Current knowledge on infection after kidney transplantation (KT) is limited. In order to offer a comprehensive guide for the management of post-transplant Leishmaniasis, we performed a systematic review following the latest PRISMA Checklist and using PubMed, Scopus, and Embase as databases. No time restrictions were applied, including all English-edited articles on Leishmaniasis in KT recipients. Selected items were assessed for methodological quality using a modified Newcastle-Ottawa Scale. Given the nature and quality of the studies (case reports and retrospective uncontrolled case series), data could not be meta-analyzed. A descriptive summary was therefore provided. Eventually, we selected 70 studies, describing a total of 159 cases of Leishmaniasis. Most of the patients were adult, male, and Caucasian. Furthermore, they were frequently living or travelling to endemic regions. The onset of the disease was variable, but more often in the late transplant course. The clinical features were basically similar to those reported in the general population. However, a generalized delay in diagnosis and treatment could be detected. Bone marrow aspiration was the preferred diagnostic modality. The main treatment options included pentavalent antimonial and liposomal amphotericin B, both showing mixed results. Overall, the outcomes appeared as concerning, with several patients dying or losing their transplant.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609696PMC
http://dx.doi.org/10.3390/tropicalmed7100258DOI Listing

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