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An Aminopyrimidone and Aminoimidazoles Alkaloids from the Rodrigues Calcareous Marine Sponge . | LitMetric

An Aminopyrimidone and Aminoimidazoles Alkaloids from the Rodrigues Calcareous Marine Sponge .

Mar Drugs

Laboratoire de Chimie et de Biotechnologie des Produits Naturels, Faculté des Sciences et Technologies, Université de La Réunion, 15 Avenue René Cassin, CS 92003, CEDEX 9, 97744 Saint-Denis, France.

Published: October 2022

AI Article Synopsis

Article Abstract

A chemical study of the CHCl-MeOH (1:1) extract from the sponge collected in Rodrigues (Mauritius) based on a molecular networking dereplication strategy highlighted one novel aminopyrimidone alkaloid compound, ernstine A (), seven new aminoimidazole alkaloid compounds, phorbatopsins D-E (, ), calcaridine C (), naamines H-I (, ), naamidines J-K (, ), along with the known thymidine (). Their structures were established by spectroscopic analysis (1D and 2D NMR spectra and HRESIMS data). To improve the investigation of this unstudied calcareous marine sponge, a metabolomic study by molecular networking was conducted. The isolated molecules are distributed in two clusters of interest. Naamine and naamidine derivatives are grouped together with ernstine in the first cluster of twenty-three molecules. Phorbatopsin derivatives and calcaridine C are grouped together in a cluster of twenty-one molecules. Interpretation of the MS/MS spectra of other compounds of these clusters with structural features close to the isolated ones allowed us to propose a structural hypothesis for 16 compounds, 5 known and 11 potentially new.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604632PMC
http://dx.doi.org/10.3390/md20100637DOI Listing

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