AI Article Synopsis
- Two new clerodane norditerpenoids, named Callintegers A and B, were discovered featuring a unique 6/6/6-fused tricyclic ring system.
- Their structures and configurations were confirmed using advanced techniques like quantum chemical calculations and X-ray diffraction.
- Compound B was found to inhibit IL-1β secretion effectively, suggesting it disrupts NLRP3 inflammasome activation, with a notable IC value of 5.5 ± 3.2 μM.
Article Abstract
Callintegers A () and B (), unprecedented clerodane norditerpenoids based on a novel carbon skeleton, were isolated from . Compounds and possess a novel 6/6/6-fused tricyclic ring system. Their structures and absolute configurations were determined by quantum chemical calculations, spectroscopic analysis, and single-crystal X-ray diffraction methods. Biological evaluation showed that compound inhibited IL-1β secretion in a dose-dependent manner with an IC value of 5.5 ± 3.2 μM. Caspase-1 maturation and IL-1β secretion were also reduced, indicating that compound impaired NLRP3 inflammasome activation.
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| http://dx.doi.org/10.1021/acs.jnatprod.2c00568 | DOI Listing |
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