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Smartphone-integrated colorimetric sensor for rapid detection of phenolic compounds based on the peroxidase-mimicking activity of copper/cerium-aspartic acid metal-organic framework.
Mikrochim Acta
January 2025
Department of Pulmonary and Critical Care Medicine, Quzhou People's Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, 324000, China.
A smartphone-integrated colorimetric sensor is introduced for the rapid detection of phenolic compounds, including 8-hydroquinone (HQ), p-nitrophenol (NP), and catechol (CC). This sensor relies on the peroxidase-mimicking activity of aspartate-based metal-organic frameworks (MOFs) such as Cu-Asp, Ce-Asp, and Cu/Ce-Asp. These MOFs facilitate the oxidation of a colorless substrate, 3,3',5,5'-tetramethylbenzidine (TMB), by reactive oxygen species (ROS) derived from hydrogen peroxide (HO), resulting in the formation of blue-colored oxidized TMB (ox-TMB).
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Alzheimers Dement
December 2024
University of Texas-Austin, Austin, TX, USA.
Background: Older adults increasingly rely on digital technologies to perform instrumental activities of daily living (iADLs), including commerce, managing accounts online, using texting and websites for social connection, and accessing health services via web platforms. Despite the increasingly central role of technology to daily life, current iADL measures do not regularly capture the digital approach to daily activities. The current study had three broad aims 1) determine the applicability of technology-based iADLs to the daily lives of older adults being evaluated for Alzheimer's disease and related dementias (ADRD), 2) compare the level of dependence for tech and traditional iADL items, and 3) determine if adding technology related iADL items improves the diagnostic accuracy of iADL assessments.
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Alzheimers Dement
December 2024
Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Netherlands.
Background: With the increasing number of potential interventions for Alzheimer's Disease (AD), there is a growing need to detect meaningful cognitive changes early in the disease. Frequent passive monitoring of smartphone behaviour, such as typing speed and precision, can give insight into the cognitive changes in AD. In the 'A personalized Medicine Approach for AD' (ABOARD)-project we investigated the reliability and validity of typing behaviour to monitor cognition in people with and without AD.
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Alzheimers Dement
December 2024
Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Background: Frontotemporal dementia (FTD) is a common young-onset dementia. Challenges to in-person FTD evaluations (e.g.
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Alzheimers Dement
December 2024
German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
Background: Frequent and remote cognitive assessment may improve sensitivity to subtle cognitive decline associated with preclinical Alzheimer's disease (AD). Our objective was to evaluate the feasibility, reliability, and construct validity of repeated remote memory assessment in late middle-aged and older adults.
Method: Participants were recruited from longitudinal aging cohorts to complete medial temporal lobe-based memory paradigms (Object-In-Room Recall [ORR], Mnemonic Discrimination for Objects and Scenes [MDT-OS], Complex Scene Recognition [CSR]) using the neotiv application on a smartphone or tablet at repeated intervals over one year.
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