In multiple sclerosis (MS) patients, trigeminal neuralgia (TN) represents a challenging syndrome to treat, often refractory to medical therapy and percutaneous techniques. Despite the frequent lack of a neurovascular conflict, the trigeminal nerve's axons are often damaged, with the myelin sheath permanently degenerated, thus explaining the difficulty in treating TN in MS. The authors illustrate trigeminal interfascicular neurolysis (the combing technique) to control refractory recurrent TN in MS: the nerve is longitudinally divided along its fibers from the root entry zone, determining good pain relief. The video can be found here: https://youtu.be/o1XksPW5fMY.
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http://dx.doi.org/10.3171/2020.5.FOCVID203 | DOI Listing |
Neurosurg Focus Video
October 2020
Neurosurgical Unit II, Department of Neurosurgery.
In multiple sclerosis (MS) patients, trigeminal neuralgia (TN) represents a challenging syndrome to treat, often refractory to medical therapy and percutaneous techniques. Despite the frequent lack of a neurovascular conflict, the trigeminal nerve's axons are often damaged, with the myelin sheath permanently degenerated, thus explaining the difficulty in treating TN in MS. The authors illustrate trigeminal interfascicular neurolysis (the combing technique) to control refractory recurrent TN in MS: the nerve is longitudinally divided along its fibers from the root entry zone, determining good pain relief.
View Article and Find Full Text PDFAnat Rec (Hoboken)
October 2017
Department of Neurosurgery, University of Utah, Salt Lake City, Utah.
The rhombomeric compartments of the hindbrain are characterized by lineage restriction; cells born in one compartment generally remain there and do not migrate to neighboring rhombomeres. Two well-known exceptions are the substantial migrations of the pontine nuclei and the mammalian facial nucleus. In this study we used Hoxa3-Cre lineage to permanently mark cells that originate in rhombomeres caudal to r4.
View Article and Find Full Text PDFJ Comp Neurol
February 2013
Neuroscience Research Australia, Randwick, New South Wales 2031, Australia.
We have found a previously unreported precerebellar nucleus located among the emerging fibers of the motor root of the trigeminal nerve in the mouse, which we have called the interfascicular trigeminal nucleus (IF5). This nucleus had previously been named the tensor tympani part of the motor trigeminal nucleus (5TT) in rodent brain atlases, because it was thought to be a subset of small motor neurons of the motor trigeminal nucleus innervating the tensor tympani muscle. However, following injection of retrograde tracer in the cerebellum, the labeled neurons in IF5 were found to be choline acetyltransferase (ChAT) negative, indicating that they are not motor neurons.
View Article and Find Full Text PDFAnat Embryol (Berl)
October 2006
Department of Anatomy and Histology, Faculty of Medicine, Medical University, Sofia 1431, Bulgaria.
A recently revealed important function of the amygdala (Am) is that it acts as the brain's "lighthouse", which constantly monitors the environment for stimuli which signal a threat to the organism. The data from patients with extensive lesions of the striate cortex indicate that "unseen" fearful and fear-conditioned faces elicit increased Am responses. Thus, also extrageniculostriate pathways are involved.
View Article and Find Full Text PDFJ Comp Neurol
April 1992
Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman 99164-6520.
Previous results indicate that the pattern of capsaicin-induced degeneration in the rat central nervous system is age-related. Experiments utilizing capsaicin's selective neurodegenerative effects to study the function of central neural circuits will therefore require a detailed understanding of capsaicin's central neurotoxicity in rats of different ages. The goal of this experiment was to characterize the degeneration induced in the rat brain by systemic treatment with capsaicin at different ages (10, 15, 20, 25, 30 or 75 days, or 11 months), using a cupric silver stain to label degenerating neurons.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!