The treatment of deafferentation pain is a primary goal of a referral center for peripheral nerve surgery. DREZ is an important asset in the neurosurgeon's armamentarium. The surgical technique and long-term results are analyzed in two series, with or without intraoperative monitoring (IOM). DREZotomy is highly effective in lumbar root avulsive injuries but is ineffective in resolving pain due to spinal cord injuries. Cervical DREZotomy for cancer pain is not superior to intrathecal morphine. In brachial plexus avulsive injuries, the largest series shows a 74% success rate, but the efficacy of the procedure is lost over time. No relevant difference has been observed since the introduction of IOM. The video can be found here: https://youtu.be/uG_kkQj5m1U.
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http://dx.doi.org/10.3171/2020.7.FOCVID2031 | DOI Listing |
Curr Med Chem
January 2025
Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva, 384012, India.
Aims: This study aimed to develop Imatinib Mesylate (IMT)-loaded Poly Lactic-co-Glycolic Acid (PLGA)-D-α-tocopheryl polyethylene glycol succinate (TPGS)- Polyethylene glycol (PEG) hybrid nanoparticles (CSLHNPs) with optimized physicochemical properties for targeted delivery to glioblastoma multiforme.
Background: Glioblastoma multiforme (GBM) is the most destructive type of brain tumor with several complications. Currently, most treatments for drug delivery for this disease face challenges due to the poor blood-brain barrier (BBB) and lack of site-specific delivery.
Front Child Adolesc Psychiatry
October 2022
Department of Anesthesiology, Yale New Haven Health System, New Haven, CT, United States.
Objectives: We sought to perform a review of emergency department data to illuminate whether there is a difference in the prevalence of severe injuries in patients with ADHD compared to patients without ADHD. We hope to illuminate whether providers should consider inquiring whether their pediatric patients have ADHD to improve long term outcomes.
Methods: This study is a retrospective cohort study of patient records contained in the TriNetX database, specifically of pediatric patients in this database who presented to an emergency department.
World J Diabetes
January 2025
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
Background: Epidemiological surveys indicate an increasing incidence of type 2 diabetes mellitus (T2DM) among children and adolescents worldwide. Due to rapid disease progression, severe long-term cardiorenal complications, a lack of effective treatment strategies, and substantial socioeconomic burdens, it has become an urgent public health issue that requires management and resolution. Adolescent T2DM differs from adult T2DM.
View Article and Find Full Text PDFJACC Adv
December 2024
Interventional Cardiology Department, Abidjan Heart Institute, Abidjan, Côte d'Ivoire.
Background: Whereas the increasing burden of acute myocardial infarction (MI) has been reported in sub-Saharan Africa, little is known about short- and long-term prognosis following acute MI.
Objectives: The purpose of this study was to assess in-hospital, 30-day, and 1-year all-cause mortality and adverse outcomes in patients with MI hospitalized at a cardiac center in Côte d'Ivoire.
Methods: This prospective cohort study used data from the REgistre des syndromes coronariens Aigus de CôTe d'IVoire (REACTIV).
JACC Adv
December 2024
Department of Cardiovascular Surgery, Mayo Clinic Rochester, Rochester, Minnesota, USA.
Background: Population-based analyses may reduce uncertainty related to referral bias and/or incomplete follow-up.
Objectives: This study analyzed long-term mortality and durability of mitral valve repair in a geographically defined population with clinical and echocardiographic follow-up.
Methods: We used the Rochester Epidemiology Project to identify 153 Olmsted County patients who underwent mitral valve repair for degenerative regurgitation from 1993 to 2018.
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