Evaluation of 3,3'-Triazolyl Biisoquinoline ,'-Dioxide Catalysts for Asymmetric Hydrosilylation of Hydrazones with Trichlorosilane.

Catalysts

Chemistry Program, Department of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, 150 West University Boulevard, Melbourne, FL 32901, USA.

Published: September 2021

A new class of axial-chiral biisoquinoline ,'-dioxides was evaluated as catalysts for the enantioselective hydrosilylation of acyl hydrazones with trichlorosilane. While these catalysts provided poor to moderate reactivity and enantioselectivity, this study represents the first example of the organocatalytic asymmetric reduction of acyl hydrazones. In addition, the structures and energies of two possible diastereomeric catalyst-trichlorosilane complexes (-HSiCl) were analyzed using density functional theory calculations.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589403PMC
http://dx.doi.org/10.3390/catal11091103DOI Listing

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