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Socio-economic outcomes among long-term childhood acute lymphoblastic leukaemia survivors enrolled between 1971 and 1998 in EORTC CLG studies: Results of the 58LAE study. | LitMetric

AI Article Synopsis

  • The study aims to assess the socio-economic outcomes of adult survivors who had childhood acute lymphoblastic leukaemia (ALL).
  • Researchers collected data from survivors enrolled in EORTC trials between 1971 and 1998 through a questionnaire, comparing results with matched control groups.
  • Findings indicate that while survivors generally have good socio-economic status, those who underwent specific treatments like stem cell transplantation and cranial radiotherapy faced more challenges, particularly in education and employment.

Article Abstract

Objective: The objective of this study is to evaluate the socio-economic outcomes of survivors of childhood acute lymphoblastic leukaemia (ALL).

Methods: Childhood ALL adult survivors, enrolled in EORTC trials between 1971 and 1998 in France and Belgium, were invited to fill out a questionnaire with information about their socio-economic situation (living with a partner, having a university degree, having a job, working part time and history of having a paid job). The outcomes were compared with two matched control populations.

Results: Among 1418 eligible patients, 507 (35.8%) participated, including 39 (8%) and 61 (12%) patients who received a haematopoietic stem cell transplantation (HSCT) and a cranial radiotherapy (CRT), respectively. The median time to follow-up was 20 years, and median age was 25 years. Survivors showed a socio-economic level at least as good as controls. HCST and CRT were associated with a higher probability of not obtaining a bachelor degree (respectively OR = 3.49, 95% CI: 1.46-8.35 and OR = 2.31, 95% CI: 1.04-5.15), HSCT was associated with unemployment (OR = 2.89, 95% CI: 1.09-7.65) and having a relapse was associated with a higher probability of not having a partner (OR = 1.88, 95% CI: 1.01-3.51) adjusting for confounders.

Conclusion: Childhood ALL survivors showed a high level of socio-economic participation. HCST and CRT were associated with poorer functioning.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787328PMC
http://dx.doi.org/10.1111/ecc.13755DOI Listing

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