Gastrostomy fed children traditionally have a Formulae diet (FD), which fulfills nutritional requirements; however, many families are adopting Blended diets (BD), which are what the whole family would eat. We undertook an observational investigation of the colonic microbiota and metabonome in a small group of gastrostomy fed children, who were either on an FD or BD, and compared, where possible to their siblings (17 FD, 28 BD, 19 HS). There was no increase in complications in tube blockage or infection rates, but a significant improvement in the prevalence of bowel problems, a reduction in medication and an increase in quality of life. Metataxonomic analysis showed that the FD group was significantly different to the Sibling group, and that families did not cluster together. Whole sample metabonomics showed no differences between groups; however, univariate analysis of biologically important metabolites did differ. Changing to a BD resulted in no increase in complications or risks, but improved the overall quality of life for the children and families.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621064 | PMC |
| http://dx.doi.org/10.1080/19490976.2022.2138661 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Long-term enteral nutrition with a nasogastric tube can be safe and effective: A case report.
Nutr Clin Pract
December 2024
Rady Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Home enteral nutrition (HEN) is a vital feeding practice for those who have chronic disorders that prevent them from eating normally. Although short-term feeding is predominantly done via nasogastric (NG) tubes and long-term feeding is done via percutaneous endoscopic gastrostomy (PEG) tube, we present a case that demonstrates that the long-term use of NG tubes may be possible. Our case involves an adult woman who has been fed via an NG tube for >3 years with no complications.
View Article and Find Full Text PDFAssociation Between Gut Microbiome Composition and Physical Characteristics in Patients with Severe Motor and Intellectual Disabilities: Perspectives from Microbial Diversity.
Nutrients
October 2024
Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, Japan.
Background: The human gut environment undergoes substantial changes as a host ages. This investigation centered on the gut microbiome diversity among patients with severe motor and intellectual disabilities (SMID), examining the association between the gut microbiome composition and physical characteristics with varying levels of diversity.
Methods: Fourteen subjects were investigated, with physical and defecation status, blood biochemical test, gut microbiome profiling, and fecal metabolites used to divide the patients into a high-diversity group (HD, eight patients) and a low-diversity group (LD, six patients).
Oropharyngeal dysphagia impact of pneumonia risk in neurological patients receiving enteral tube feeding: Insights from a gastroenterologist.
Neurogastroenterol Motil
January 2025
Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Article Synopsis
- - Oropharyngeal dysphagia is common in neurological patients and can lead to serious issues like aspiration pneumonia, often requiring long-term feeding through methods like NGT or PEG.
- - A study from 2015 to 2022 examined pneumonia risk in these patients, finding that those with a history of pneumonia or on enteral feeding had a higher risk, but PEG users had a significantly lower risk of hospitalization due to pneumonia compared to NGT users.
- - The study suggests using Modified Flexible Endoscopic Evaluation of Swallowing (mFEES) for screening dysphagia and recommends PEG feeding as the safer option for reducing pneumonia risks in patients with swallowing difficulties.
The impact of an enteral formula with food-derived ingredients on dietetic practice at a specialist children's hospital in the UK: Retrospective study.
J Hum Nutr Diet
February 2025
Department of Biometry Statistics, Sofpromed Clinical Investigation, Palma de Mallorca, Spain.
Background: Blended tube feeds are reported to be better tolerated in some children compared to standard commercial enteral formulas, allowing children to normalise feeding by having similar foods as the rest of the family. However, a blended tube feed is contraindicated in patients who are immunocompromised or require post-pyloric feeding as a result of a food safety risk. Other contraindications for blended diet include children who require continuous pump feeding via gastrostomy or nasogastric feeding tube (< 12 Fr) and fluid restrictions.
View Article and Find Full Text PDFMultiple ASM Administration via Percutaneous Feeding Tube as a Cause of Pseudo-Refractoriness Leading to Recurrent Seizure Clusters.
Neurol India
July 2024
Department of Neurology, Fortis Hospital, Mumbai, Maharashtra, India.
It is important to identify true refractoriness of seizures, before escalation of anti-seizure medications, to avoid side effects of medications. Bioavailability of medications changes with the formulations used and changes significantly with the route of administration. Both of these were significantly impacted in a lady who was being fed via percutaneous endoscopic gastrostomy (PEG) feeds and deemed refractory to medications.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!