AI Article Synopsis
- A study reveals how different mechanisms help balance gene dosage between sex chromosomes (like the X chromosome) and autosomes in various organisms.
- Researchers identified a crucial factor that enhances the activity of the X chromosome during early development in mice.
- The study also links issues with this X chromosome upregulation to the development of bile duct cancer in humans.
Article Abstract
Dosage balance between sex chromosomes and autosomes can be achieved through diverse mechanisms across vertebrates and invertebrates. A new study discovers a key player that contributes to X chromosome upregulation (XCU) during early mouse development and associates the dysregulation of XCU with human bile duct cancer pathogenesis.
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| http://dx.doi.org/10.1016/j.cub.2022.09.027 | DOI Listing |
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