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Model compounds for evaluating the reactivity of amphetamine-type stimulants.
Forensic Sci Int
July 2024
Deakin University, Centre for Sustainable Bioproducts, School of Life and Environmental Sciences, Waurn Ponds, Australia. Electronic address:
The use of controlled precursors for reaction optimisation is not always practical. One approach to limiting the use of controlled substances is to instead use 'model compounds'. Herein, two model compounds resembling norephedrine and ephedrine were selected based on their (i) structural similarity (i.
View Article and Find Full Text PDFContractile Effects of Amphetamine, Pseudoephedrine, Nor-pseudoephedrine (Cathine), and Cathinone on Atrial Preparations of Mice and Humans.
J Cardiovasc Pharmacol
March 2024
Institute for Pharmacology and Toxicology, Medical Faculty, Martin Luther University Halle-Wittenberg, Halle, Germany; and.
Amphetamine derivatives are used worldwide legally or illegally and intoxications may be accompanied by cardiac arrhythmias. Here, we tested contractile effects of cumulative applied (±)-amphetamine, pseudoephedrine, nor-pseudoephedrine (cathine), and cathinone in electrically stimulated (1 Hz) human right atrial preparations (HAP) and mouse left atrial preparations and in spontaneously beating mouse right atrial preparations. In mouse atrial preparations, amphetamine increased force of contraction and beating rate in a concentration- and time-dependent manner, starting at 1 µM in left atrial preparations to 157.
View Article and Find Full Text PDFPotential drug-drug interactions with phentermine among long-term phentermine consumers: A retrospective analysis.
S Afr Med J
August 2023
Medicine Usage in South Africa (MUSA), Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
Background: Phentermine is an internationally recognised amphetamine derivative with significant appetite-suppressing properties. The drug is indicated for the short-term management of obesity, as the long-term (LT) use of phentermine may potentially be associated with severe cardiovascular side-effects, abuse and dependence. The LT use hereinafter describes periods exceeding 12 consecutive weeks.
View Article and Find Full Text PDFCardiac effects of ephedrine, norephedrine, mescaline, and 3,4-methylenedioxymethamphetamine (MDMA) in mouse and human atrial preparations.
Naunyn Schmiedebergs Arch Pharmacol
February 2023
Institute for Pharmacology and Toxicology, Medical Faculty, Martin Luther University Halle-Wittenberg, Magdeburger Str. 4, D-06097, Halle, Germany.
Article Synopsis
- Recreational drugs like ephedrine, norephedrine, MDMA, and mescaline can cause serious health risks, including cardiac issues and potential death, particularly from arrhythmias.
- A study examined the effects of these drugs on the contraction force and rate in isolated mouse and human heart tissue, finding that ephedrine, norephedrine, and MDMA increased heart contraction and beating rates, while mescaline did not have the same effect.
- The positive effects of the first three drugs were linked to increased protein phosphorylation in the heart tissue and could be blocked by substances like cocaine or propranolol, suggesting they act as indirect sympathomimetic drugs.
Phytochemical and Biological Screening of Leaf, Bark and Fruit Extracts from Wall.
Life (Basel)
August 2021
Department of Botany, Islamia College University, Peshawar 25120, Khyber Pakhtunkhwa, Pakistan.
The Aquifoliaceae is an important family and has been used traditionally for some time. One of the members of this family is the wall, which itself possesses a potential medicinal importance. This plant is traditionally used for the treatment of various ailments including pain, swelling, burns, and fever.
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