AI Article Synopsis
- Researchers investigated the rhizomes of a plant from the Polygonaceae family and identified six anthraquinone compounds, including chrysophanol and emodin.
- These compounds were characterized using mass spectrometry (MS) and nuclear magnetic resonance (NMR) techniques by comparing them with existing literature.
- Emodin was found to have the strongest antileishmanial activity, and this study is notable for reporting the antileishmanial effects of these specific compounds for the first time.
Article Abstract
Phytochemical investigation of the rhyzomes of (Polygonaceae) afforded six anthraquinones viz chrysophanol (), physcion (), emodin (), mixture of physcion-8--,D-glucopyranoside () and chrypsophanol-8--,D-glucopyranoside (), and emodin-8--,D-glucopyranoside (). All the compounds were characterised and identified by comparison of their MS and NMR data with available literature data. The isolated compounds were evaluated for their antileishmanial activity. Emodin () was the most active compounds with IC 13.82 and 0.26µg/mL against amastigotes and promastigotes, respectively. Emodin-8--,D-glucopyranoside () also showed a moderate activity with IC 27.53 and 37.08 µg/mL. This is the first report of antileishmanial compounds from and the antileishmanial activities of compounds , , and are here reported for the first time.
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| http://dx.doi.org/10.1080/14786419.2022.2137797 | DOI Listing |
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