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"If that would have lessened my symptoms, that would have been great...": a qualitative study about the acceptability of tecovirimat as treatment for mpox.
BMC Med
January 2025
Health Emergencies Programme, World Health Organization, Geneva, Switzerland.
Background: Tecovirimat, an antiviral treatment for smallpox, was approved as a treatment for mpox by the European Medicines Agency in January 2022. Approval was granted under "exceptional circumstances" based on effectiveness found in pre-clinical challenge studies in animals and safety studies in humans showing minimal side effects. As clinical efficacy studies are still ongoing, there is currently limited information with regard to the acceptability of tecovirimat to treat mpox.
View Article and Find Full Text PDFNavigating the fear: assessing nursing students' concerns and preventive practices in response to Monkeypox in Egypt.
BMC Nurs
January 2025
Psychiatric and Mental Health Nursing, Faculty of Nursing, Alexandria University, Alexandria, Egypt.
Background: Monkeypox has emerged as a global health concern, necessitating preventive measures and awareness among healthcare students. Understanding nursing students' fears, concerns, and preventive practices regarding Monkeypox can help improve preparedness and response strategies.
Aim: This study aimed to assess the levels of fear, concerns, and preventive practices related to monkeypox among nursing students at Beni Suef University, Egypt, during the 2024-2025 academic year.
Evolutionary variation of the monkeypox virus detected for the first time in Nantong, Jiangsu.
Virol J
December 2024
Key Laboratory of Medicine, Nantong Center for Disease Control and Prevention, 189 GongnongnanRoad, Chongchuan District, Nantong, 226007, China.
Article Synopsis
- Monkeypox (MPOX) is caused by the Orthopoxvirus monkeypox (MPXV) and presents symptoms akin to smallpox, with ongoing outbreaks raising global public health concerns, especially in the Democratic Republic of the Congo and recently in China.
- A new lineage of MPXV (C.1.1) was identified from samples in a Nantong outbreak, possibly linked to cases imported from Japan.
- Genomic analysis revealed reduced mutations in MPXV and specific mutations in proteins that could affect its evolution and vaccine development, indicating potential research directions for understanding the virus.
CDCM: a correlation-dependent connectivity map approach to rapidly screen drugs during outbreaks of infectious diseases.
Brief Bioinform
November 2024
School of Mathematics and Statistics, HNP-LAMA, Central South University, Changsha 410083, Hunan, China.
In the context of the global damage caused by coronavirus disease 2019 (COVID-19) and the emergence of the monkeypox virus (MPXV) outbreak as a public health emergency of international concern, research into methods that can rapidly test potential therapeutics during an outbreak of a new infectious disease is urgently needed. Computational drug discovery is an effective way to solve such problems. The existence of various large open databases has mitigated the time and resource consumption of traditional drug development and improved the speed of drug discovery.
View Article and Find Full Text PDFMonkeypox: A comprehensive review on mutation, transmission, pathophysiology, and therapeutics.
Int Immunopharmacol
January 2025
School of Chemical and Biomolecular Engineering, Pusan National University, Busan, South Korea. Electronic address:
Monkeypox virus (MPXV) is the causative agent of the monkeypox (Mpox) disease, belongs to the Orthopoxvirus genus of the Poxviridae family. Due to the recent re-emergence of Mpox in 2024, this is the second time when the World Health Organization (WHO) declared Mpox as a Public Health Emergency of International Concern (PHEIC). This review intends to offer an in-depth analysis of Mpox, including its key characteristics, epidemiological, mutation, pathophysiology, transmission, and therapeutics.
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