AI Article Synopsis
- Cardiac sarcoidosis (CS) is a serious inflammatory heart disease that can cause significant health issues like arrhythmias and heart failure.
- Recent advancements in cardiac imaging, particularly [F]FDG PET and [I]BMIPP SPECT, have enhanced the detection of CS by identifying inflammation and damage in the heart.
- [F]FDG PET is the primary method for spotting myocardial inflammation, while [I]BMIPP SPECT helps reveal both early and advanced damage, suggesting that using both imaging techniques together could improve diagnosis and treatment of CS.
Article Abstract
Purpose Of Review: Cardiac sarcoidosis (CS) is an inflammatory disease of unknown etiology that can lead to life-threatening arrhythmias, heart failure, and death. Advanced cardiac imaging modalities have improved the clinician's ability to detect this disease. The purpose of this review is to discuss the recent evidence of cardiac metabolic imaging as assessed by [F]FDG PET and [I]BMIPP SPECT in the evaluation of CS patients.
Recent Findings: [F]FDG PET is the gold standard to identify myocardial inflammation. [I]BMIPP SPECT can uncover early myocardial damage as well as advanced stages of CS when fibrosis prevails. In presence of inflammation, myocardial [F]FDG uptake is increased, but in contrast, BMIPP myocardial uptake is reduced or even suppressed. Thus, a complementary role of cardiac metabolic imaging by [F]FDG PET and BMIPP SPECT has been proposed to detect the whole spectrum of CS. [F]FDG PET is considered an important tool to improve the diagnosis and optimize the management of CS. The role of [I]BMIPP SPECT in diagnosing CS is still under investigation. Further studies are needed to evaluate the clinical utility of combined cardiac metabolic imaging in the diagnosis, prognosis, and for selecting treatments in CS patients.
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| http://dx.doi.org/10.1007/s11886-022-01803-4 | DOI Listing |
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