AI Article Synopsis
- Diacerein (DCN) is a nonsteroidal anti-inflammatory drug currently used for osteoarthritis and has received fast-track development status for treating epidermolysis bullosa (EB) due to its disease-modifying properties and pain relief benefits.
- The compound also shows promise in treating various disorders such as renal disease and diabetes by exhibiting antioxidant and anti-apoptotic effects.
- The review covers diacerein’s mechanisms in managing different types of pain, including neuropathic and inflammatory pain, and suggests that further clinical trials are needed to explore its effectiveness alone or with existing therapies.
Article Abstract
Diacerein (DCN), an analogue of rhein (a glycosidal compound of natural origin), is currently used in the treatment of osteoarthritis and is given a fast-track designation for development to treat epidermolysis bullosa (EB). It is a nonsteroidal anti-inflammatory drug having disease-modifying properties in osteoarthritis and anti-inflammatory effects for the treatment of EB. Diacerein has a beneficial effect on pain relief and demonstrated antioxidant and anti-apoptotic effects, which are useful in renal disease, diabetes, and other disorders. This review discusses the possible mechanism of diacerein in the management of pain. The potential role of rhein and diacerein in the treatment of neuropathic, inflammatory and nociceptive pain is also reviewed. The effect of diacerein and rhein on mediators of pain, such as transient receptor potential cation channel subfamily V (TRPV1), Substance P, glutamate, inflammatory cytokines, nitric oxide, matrix metalloproteinases, histamine, palmitoylethanolamide, nuclear factor-kappa B (NFkB), and prostaglandin, has also been discussed. The data highlights the role of diacerein in neuropathic, nociceptive and inflammatory pain. Clinical trials and mechanism of action studies are needed to ascertain the role of diacerein, rhein or their analogues in the management of pain, alone or in combination with other approved therapies.
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| http://dx.doi.org/10.2174/2589977514666220428124623 | DOI Listing |
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