AI Article Synopsis
- - The study focuses on understanding early cancer recurrence in patients with unresectable locally advanced non-small cell lung cancer (LA-NSCLC) who received concurrent chemoradiotherapy (CRT), aiming to identify clinical characteristics and risk factors associated with such recurrences.
- - Out of 46 patients reviewed, 37% experienced recurrence within one year, with findings showing that lower body mass index and tumor proportion scores (TPS) indicated a higher likelihood of early recurrence.
- - The research concludes that lower TPS expression is an independent risk factor for early recurrence, suggesting that these patients require closer monitoring post-treatment to improve survival outcomes.
Article Abstract
Background: The clinical characteristics and risk factors for cancer recurrence have not been well evaluated regarding early recurrence in patients with unresectable locally advanced non-small cell lung cancer (LA-NSCLC) who receive concurrent chemoradiotherapy (CRT). The aim of this study was to determine the clinical characteristics and risk factors of patients with stage III unresectable LA-NSCLC treated with CRT who developed early recurrence.
Methods: We retrospectively reviewed the clinical records of 46 patients diagnosed with stage III unresectable LA-NSCLC treated with CRT at our center between July 2012 and July 2021. A tumor proportion score (TPS) < 50% was defined as "low expression" and a TPS > 50% was defined as "high expression."
Results: A total of 17 (37.0%) patients had a confirmed recurrence within 1 year of treatment. More patients had a lower body mass index in the early recurrence group than in the later recurrence group (p = 0.038). A higher number of patients in the late recurrence group underwent surgery after CRT (p = 0.036). Patients with a higher TPS were more likely to experience late recurrence than early recurrence (p = 0.001), whereas more patients with stage N3 disease were in the early recurrence group (p = 0.011). Multivariate analysis identified lower TPS expression as an independent risk factor for early recurrence after CRT. Overall survival was prolonged in the late recurrence group (p < 0.001).
Conclusions: A lower TPS may be a predictor of early recurrence after CRT in patients with LA-NSCLC. These patients should be closely monitored for post-treatment recurrence.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750816 | PMC |
| http://dx.doi.org/10.1111/1759-7714.14704 | DOI Listing |
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