In recent years, genetic testing using next-generation sequencers has become widespread in the field of cancer drug therapy, and treatments based on individual genetic disorders are now routinely used. Drug development is underway to target various fusion genes among the detected genetic disorders. However, the functional significance of most of the detected fusion genes is unknown, and it is necessary to understand their biological characteristics and elucidate their functions for the development of personalized medicine. We review the molecular biology, detection, and treatment of cancer fusion genes from a pan-cancer perspective.
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