Medicine (Baltimore)
Department of Gastroenterology, the Affiliated Hospital of Qingdao University, Qingdao, China.
Published: October 2022
Rationale: Intestinal stricture and obstruction are rare complications of ulcerative colitis (UC). Currently, there are only a few studies on the treatment of UC with intestinal stenosis, however there are no reports on the treatment of UC with benign intestinal stenosis with ustekinumab (UST).
Patient Concerns: A 22-year-old woman was admitted to our hospital due to a 3-year history of recurrent bloody mucous in stool with intermittent abdominal pain and distension developed in the past month. She was steroid-dependent and had developed a secondary loss of response to infliximab.
Diagnoses: She was diagnosed with UC combined with incomplete intestinal obstruction due to stenosis. The stricture had a mixed pattern with both inflammatory and fibrotic components, with the former covering a larger section of the intestine.
Interventions: The patient was given UST for 56 weeks.
Outcomes: The patient's symptoms subsided after treatment with UST. The ulcers healed, and the stenosis was reduced.
Lessons: UST is effective against UC with benign intestinal stenosis. It is thought that UST inhibits the production of transforming growth factor-β and interleukin-17, leading to the suppression of myofibroblast proliferation, ultimately alleviating intestinal stenosis.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592401 | PMC |
http://dx.doi.org/10.1097/MD.0000000000031213 | DOI Listing |
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