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Safety evaluation of medroxyprogesterone acetate: a pharmacovigilance analysis using FDA adverse event reporting system data.
Front Pharmacol
December 2024
Department of Obstetrics and Gynecology, Second Hospital of Hebei Medical University, Shijiazhuang, China.
Background: Medroxyprogesterone acetate (MPA), a synthetic progestogen, is extensively used for the treatment of various conditions, including contraception, irregular menstruation, functional uterine bleeding, and endometriosis. However, like all pharmaceutical agents, MPA is associated with adverse drug reactions. This study aimed to evaluate the adverse events (AEs) associated with MPA in by analyzing real-world data from the U.
View Article and Find Full Text PDFIdentifying and Understanding Seizure Liability in Drug Development.
Int J Toxicol
January 2025
Allucent, Cary, NC, USA.
Seizures are complex electrophysiological disturbances affecting one or more populations of brain neurons. Seizures following test article (TA) exposure pose significant challenges in drug development. This paper considers the diverse neurological manifestations, mechanisms, and functional and structural assessments needed to investigate TA-related seizure liabilities, with a particular focus on nonclinical species.
View Article and Find Full Text PDFPerformance of Ulcer Features in Predicting Malignancy Among Gastric Ulcers Diagnosed on Upper Endoscopy.
J Clin Gastroenterol
December 2024
Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX.
Objective: Even though the prevalence of malignancy within gastric ulcers is low, surveillance endoscopy is routinely performed after gastric ulcer diagnosis resulting in unnecessary costs and risks. Endoscopic appearance may be used to identify ulcers with malignant features and guide decisions regarding the need for surveillance endoscopy. Our aim was to assess the predictive value of several endoscopic ulcer features with the risk of prevalent malignancy in patients diagnosed with gastric ulcers.
View Article and Find Full Text PDFDental arch dimensional changes in deep bite adults treated with orthodontic fixed appliances in conjunction with maxillary incisor vs. canine bite turbos during the levelling and aligning phase: a randomized clinical trial.
Clin Oral Investig
January 2025
Orthodontic Section, Department of Preventive Dentistry, Faculty of Dentistry, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand.
Introduction: This randomized clinical trial compared arch dimensional changes, dentoskeletal changes, and the rate of overbite correction in deep bite adults treated with fixed appliances and either maxillary incisor bite turbos (IBT) or canine bite turbos (CBT).
Materials And Methods: Forty-six deep bite subjects treated with fixed appliances were randomized into IBT (n = 23) and CBT (n = 23) groups. Changes in intercanine width (ICW), arch height (AH), and Little's Irregularity Index (LII) were analyzed from before treatment (T) to 3 months after aligning with 0.
Orthodontic Treatment Need and Its Relation to Gender, Oral Hygiene, and Age Range in a Mexican Population.
Cureus
December 2024
Clinical Research Laboratory, Faculty of Stomatology, Autonomous University of San Luis Potosí, San Luis Potosí, MEX.
Introduction Malocclusion, a prevalent oral health concern, significantly impacts both functional abilities and psychosocial well-being. The Dental Aesthetic Index (DAI) is widely used to assess malocclusion severity and orthodontic treatment needs. This study aims to evaluate the prevalence of orthodontic treatment needs based on the DAI in a Mexican population, considering factors such as gender, oral hygiene, and age range.
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