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Kingella kingae Induced Septic Arthritis in the Knee Revealing an Unexpected Diagnosis of Multiple Myeloma, a Case Report.
J Orthop Case Rep
December 2024
Department of Orthopedic Surgery, Regions Hospital Horsens, Horsens, Denmark.
Introduction: Kingella kingae has become an increasingly significant cause of osteoarticular infection in children under the age of 4. The bacteria is infrequent in adults. Previous reports have indicated its association with infections, primarily affecting immunocompromised individuals.
View Article and Find Full Text PDFDevelopment of a deep learning model for automated detection of calcium pyrophosphate deposition in hand radiographs.
Front Med (Lausanne)
October 2024
Department of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Article Synopsis
- CPPD disease is a significant cause of arthritis that can resemble other rheumatic conditions, making accurate diagnosis crucial.
- A deep-learning algorithm was developed and tested to automatically detect CPPD features in hand radiographs, focusing specifically on certain joint areas.
- The combined model for detecting CPPD showed strong performance metrics, with a mean AUROC of 0.86 and good sensitivity and specificity, while separate models for different joint areas had varying success rates.
Safety and efficacy of filgotinib in Japanese patients with rheumatoid arthritis: Week 156 interim results in FINCH 4.
Mod Rheumatol
November 2024
Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, and Saitama Medical University, Saitama, Japan.
Objectives: To describe safety and efficacy of filgotinib 200 or 100 mg (FIL200/FIL100) in Japanese patients with rheumatoid arthritis in a long-term extension (LTE; NCT03025308).
Methods: Patients who completed any of three parent studies (NCT02889796: inadequate response [IR] to methotrexate [MTX]; NCT02873936: IR to biologic disease-modifying antirheumatic drugs; NCT02886728: MTX-naïve) without rescue therapy could enter the LTE; patients taking FIL continued their dosage, and those who received comparators were rerandomised to FIL200 or FIL100. This analysis includes week 156 interim results.
Key Clinical Massage: Although tumor necrosis factor (TNF) inhibitors are used to prevent autoimmune disease, but they can cause adverse effects. Multiple sclerosis syndrome is one of the rare complications following treatment with TNF inhibitor. We reported a case of rheumatoid arthritis with unfavorable outcome post Etanerecept therapy.
View Article and Find Full Text PDFBackground: Janus kinase inhibitors are an effective option for achieving sustained remission or low disease activity in patients with rheumatoid arthritis (RA) following inadequate response to conventional synthetic disease-modifying anti-rheumatic drugs. Filgotinib is a Janus kinase 1-preferential inhibitor available in two doses for moderate-to-severe RA. We report the long-term efficacy and safety of filgotinib.
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