AI Article Synopsis
- * The exact role of these autoantibodies in the development of ASSD is still not fully understood, but they seem to be crucial in the disease's pathogenesis.
- * The study suggests that ASSD may involve the release of aaRSs from cells and highlights the potential role of extracellular tRNAs in triggering immune responses, particularly through Toll-like receptors.
Article Abstract
Antisynthetase syndrome (ASSD) is an autoimmune disease characterized by circulating autoantibodies against one of eight aminoacyl-tRNA synthetases (aaRSs). Although these autoantibodies are believed to play critical roles in ASSD pathogenesis, the nature of their roles remains unclear. Here we describe ASSD pathogenesis and discuss ASSD-linked aaRSs - from the WHEP domain that may impart immunogenicity to the role of tRNA in eliciting the innate immune response and the secretion of aaRSs from cells. Through these explorations, we propose that ASSD pathogenesis involves the tissue-specific secretion of aaRSs and that extracellular tRNAs or tRNA fragments and their ability to engage Toll-like receptor signaling may be important disease factors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974581 | PMC |
| http://dx.doi.org/10.1016/j.tibs.2022.09.011 | DOI Listing |
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