AI Article Synopsis
- Women with breast cancer (BC) experience reduced exercise tolerance and fatigue, similar to those with heart failure with preserved ejection fraction (HFpEF), impacting their physical function and quality of life.
- The review examines how issues in oxygen transport, particularly through cardiac, vascular, and skeletal muscle functions, contribute to exercise intolerance in BC survivors.
- It suggests that chemotherapy and unhealthy lifestyle choices may heighten the risk of developing HFpEF in women who have undergone treatment for breast cancer.
Article Abstract
Reduced exercise tolerance and fatigue are hallmark features in both breast cancer (BC) and heart failure with preserved ejection fraction (HFpEF) and are associated with decreased physical function and quality of life. This brief review focuses on the mechanisms of exercise intolerance in women with BC across the survivorship continuum and highlights how these disturbances within the oxygen transport cascade are similar to that of HFpEF patients. Specifically, the role that impaired cardiac, peripheral vascular and skeletal muscle function play in limiting peak oxygen uptake are discussed. We propose that women with BC are at increased risk of developing HFpEF potentially due to the adverse effects of chemotherapy and concurrent adverse lifestyle behaviors on cardiovascular and skeletal muscle function.
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| http://dx.doi.org/10.1016/j.pcad.2022.10.005 | DOI Listing |
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