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Serum and plasma as a good candidates of body fluids for detection lung cancer by FTIR liquid biopsy.
Sci Rep
December 2024
Department of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093, Lublin, Poland.
Using Fourier Transform Infrared spectroscopy (FTIR), it is possible to show chemical composition of materials and / or profile chemical changes occurring in tissues, cells, and body fluids during onset and progression of diseases. For diagnostic application, the use of blood would be the most appropriate in biospectroscopy studies since, (i) it is easily accessible and, (ii) enables frequent analyses of biochemical changes occurring in pathological states. At present, different studies have investigated potential of serum, plasma and sputum being alternative biofluids for lung cancer detection using FTIR.
View Article and Find Full Text PDFDeep learning on CT scans to predict checkpoint inhibitor treatment outcomes in advanced melanoma.
Sci Rep
December 2024
Medical Image Analysis, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Immune checkpoint inhibitor (ICI) treatment has proven successful for advanced melanoma, but is associated with potentially severe toxicity and high costs. Accurate biomarkers for response are lacking. The present work is the first to investigate the value of deep learning on CT imaging of metastatic lesions for predicting ICI treatment outcomes in advanced melanoma.
View Article and Find Full Text PDFMechanical evaluation and optimal mixing ratios in co-disposal of phosphate mining tailings and waste rock.
Sci Rep
December 2024
Department of Civil and Environmental Engineering, University of Brasília, Brasília, 70910-900, Brazil.
Given the complexity of the behavior of mining tailings dams built by the technique of hydraulic embankments and the recurring dam ruptures globally, especially in Brazil, ensuring enhanced safety through advanced disposal techniques becomes crucial. While the co-disposal method has been extensively explored for various mineral substances, a notable gap exists in the literature concerning its application specifically to tailings and waste rock generated from phosphate mining operations. This study aims to identify the optimal ratio for a mining tailings and waste rock mixture and evaluate its mechanical behavior in comparison to individual materials.
View Article and Find Full Text PDFDiagnostic characteristics of pediatric cyclic vomiting syndrome.
J Pediatr Gastroenterol Nutr
December 2024
Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Objectives: Cyclic vomiting syndrome (CVS) remains a diagnostic challenge due to its nonspecific presentation despite consensus-based diagnostic criteria. There is a need for improved, evidence-based diagnostic criteria. We hypothesized that symptoms differ quantitatively between children with CVS versus other vomiting conditions and that current diagnostic criteria are not sufficiently sensitive for diagnosing CVS.
View Article and Find Full Text PDFIntroduction: Dozens of vaccines have been approved or authorized internationally in response to the ongoing SARS-CoV-2 pandemic, covering a range of modalities and routes of delivery. For example, mucosal delivery of vaccines via the intranasal (i.n.
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