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Tailored cancer therapy by magnetic nanoparticle hyperthermia: A virtual scenario simulation method. | LitMetric

Tailored cancer therapy by magnetic nanoparticle hyperthermia: A virtual scenario simulation method.

Comput Methods Programs Biomed

Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM), Universitat Politècnica de València (UPV), Universitat de València (UV), Valencia, Spain; CIBER in the Subject Area of de Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain; ITIS Foundation for Research on Information Technologies in Society, Zurich, Switzerland.

Published: November 2022

AI Article Synopsis

Article Abstract

Background And Objective: Hyperthermia is a cancer treatment aiming to induce cell death by directly warming cancerous tissues above 40 °C. This technique can be applied both individually and together with other cancer therapies. The main challenge for researchers and medics is to heat only tumoral cells avoiding global or localized heating of sane tissues. The objective in this study is to provide a realistic virtual scenario to develop an optimized multi-site injection plan for tailored magnetic nanoparticle-mediated hyperthermia applications.

Methods: A three-dimensional model of a cat's back was tested in three different simulation scenarios, showing the impact of magnetic nanoparticles in each specific environment configuration.

Results: As a result of this study. This simulation method can, minimising the affection to healthy tissue.

Conclusions: This virtual method will help real and personalized therapy planning and tailor the dose and distribution of magnetic nanoparticles for an enhanced hyperthermia cancer treatment.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmpb.2022.107185DOI Listing

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