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Mitophagy Regulates Kidney Diseases.
Kidney Dis (Basel)
December 2024
Research Center of Clinical Pharmacy of The First Affiliated Hospital and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.
Background: Mitophagy is a crucial process involved in maintaining cellular homeostasis by selectively eliminating damaged or surplus mitochondria. As the kidney is an organ with a high dynamic metabolic rate and abundant mitochondria, it is particularly crucial to control mitochondrial quality through mitophagy. Dysregulation of mitophagy has been associated with various renal diseases, including acute and chronic kidney diseases, and therefore a better understanding of the links between mitophagy and these diseases may present new opportunities for therapeutic interventions.
View Article and Find Full Text PDFFenestrated Endothelial Cells across Organs: Insights into Kidney Function and Disease.
Int J Mol Sci
August 2024
Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27710, USA.
In the human body, the vascular system plays an indispensable role in maintaining homeostasis by supplying oxygen and nutrients to cells and organs and facilitating the removal of metabolic waste and toxins. Blood vessels-the key constituents of the vascular system-are composed of a layer of endothelial cells on their luminal surface. In most organs, tightly packed endothelial cells serve as a barrier separating blood and lymph from surrounding tissues.
View Article and Find Full Text PDFShaping the future of kidney genetics in Australia: proceedings from the KidGen policy implementation workshop 2023.
Hum Genomics
August 2024
The KidGen Collaborative, Australian Genomics, Melbourne, VIC, Australia.
The KidGen Collaborative's Policy Implementation Workshop 2023 celebrated the 10th anniversary of Australia's first kidney genetics clinic in Brisbane. This event marked the establishment of a national network now comprising 19 kidney genetics clinics across Australia, all dedicated to providing equitable access to genomic testing for families affected by genetic kidney diseases. The workshop reflected on past progress and outlined future objectives for kidney genetics in Australia, recognising the collaborative efforts of clinical teams, researchers, and patients.
View Article and Find Full Text PDFGenetic Causes of Nephrotic Syndrome and Focal and Segmental Glomerulosclerosis.
Adv Kidney Dis Health
July 2024
Division of Nephrology, University Health Network, Toronto, Ontario, Canada; Division of Nephrology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address:
Article Synopsis
- Nephrology is focused on understanding the genetic causes of nephrotic syndrome (NS) to gain insights into chronic kidney disease, particularly highlighting that NS and focal segmental glomerulosclerosis are podocyte disorders.* -
- Identifying a single gene cause (monogenic diagnosis) is more likely with a positive family history and can help in family screening and reproductive counseling.* -
- Advances in genomic studies reveal a complex genetic architecture influencing NS, with potential for personalized medicine through targeted treatments, though further research is needed to confirm their effectiveness.*
Genome editing and kidney health.
Clin Kidney J
May 2024
Bristol Renal, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, UK.
Article Synopsis
- CRISPR-Cas technologies have transformed genetic engineering, showing potential in treating genetic diseases like chronic kidney disease (CKD), which can be caused by different mutations.
- Recent advances in genomic sequencing combined with CRISPR enable precise correction of mutations, especially in monogenic diseases, offering hope for treating conditions such as polycystic kidney disease and Alport syndrome.
- Innovations like prime editing and base editing improve genome editing efficiency and specificity without causing harmful DNA breaks, but challenges remain in developing effective delivery methods for therapies.
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