Anti-HIV crotocascarin ω from Kenyan .

An anti-HIV methanol-soluble fraction of a 1:1 CHCl:CHOH extract of twigs of a Kenyan yielded seven compounds, the new crotocascarin ω (), the known β-oplopanone (), dihydroconiferyl acetate (), 3'(4''-hydroxyphenyl)-propyl benzoate (), lupeol, sitosterol and stigmasterol. Crotocascarin ω (90%) inhibited HIV-1 replication with an IC value of 5.3 nM, and the compound was cytotoxic towards MT-4 cells presenting an IC value of 84 µM. modelling showed that the anti-HIV activity for compound could be through the HIV-1 protease inhibition.